Febuxostat对痛风伴高尿酸血症患者的血液流变学和血小板活化功能的影响  

Effect of febuxostat on blood rheology and platelet activation in patients with gout and hyperuricemia

作　　者：刘青员[1] 祁广东 陈鑫[2] LIU Qing-yuan;QI Guang-dong;CHEN Xin(Dept.of Endocrinology,Binhai People s Hospital,Binhai 224500;Dept.of Neurology,Hospital Affiliated to Nantong University,Nantong 226001,China)

机构地区：[1]江苏省滨海县人民医院内分泌科,江苏滨海224500 [2]南通大学附属医院神经内科,江苏南通226001

出　　处：《基础医学与临床》2018年第11期1568-1571,共4页Basic and Clinical Medicine

摘　　要：目的探讨febuxostat(非布司他)对痛风伴高尿酸血症患者血液流变学及血小板活化功能的影响。方法选取滨海县人民医院2015年4月至2017年3月收治的痛风伴高尿酸血症患者68例,随机分为对照组(35例)(给予别嘌醇治疗)和观察组(33例)(给予febuxostat治疗)。比较两组患者的临床疗效、血液流变学变化以及血小板活化功能的变化。结果治疗总有效率,观察组患者高于对照组患者(P<0. 05),与对照组相比,观察组患者在治疗后的血液流变学指标改善和血小板活化功能改善方面均更为明显(P<0. 05)。结论 Febuxostat治疗能有效地降低痛风伴高尿酸血症患者的高尿酸状态,改善患者的血液流变学与血小板活化功能,疗效优于别嘌醇。Objective To investigate the effect of febuxostat on blood rheology and platelet activation in patients with gout and hyperuricemia.Methods Sixty-eight cases of patients with gout and hyperuricemia were collected in Binhai People s Hospital from April 2015 to March 2017.They were randomly divided into the control group(35 cases),received allopurinol treatment,and the observation group(33 cases)treated with febuxostat.The clinical effects,blood rheology and the change of platelet activation function were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Compared with the control group,the improvement of blood rheology and platelet activation function in the observation group were more significant than those in the control group(P<0.05).Conclusions Febuxostat therapy can effectively reduce uric acid level in patients with gout and hyperuricemia;improve blood rheology and platelet activation function in patients with gout and hyperuricemia,and the curative effect is better than that of allopurinol.

关 键 词：FEBUXOSTAT 别嘌醇 高尿酸血症 痛风 血液流变学 血小板活化功能 

分 类 号：R589.7[医药卫生—内分泌]