miRNA-590表达水平与乳腺癌患者临床病理特征及预后的关系  

Relationship between miR-590 expression and clinicopathological characteristics and prognosis in breast cancer patients

作　　者：颜仕鹏[1] 吴雯琼 秦昂[1] 吕捷 YAN Shi-peng;WU Wen-qiong;QIN Ang;Lv Jie(Hunan Cancer Hospital,Changsha,Hunan 410000)

机构地区：[1]湖南省肿瘤医院,湖南长沙410000

出　　处：《赣南医学院学报》2018年第9期889-894,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:评估mi RNA-590表达水平与乳腺癌患者临床病理特征及预后的关系。方法:收集某三甲医院2011年至2016年期间271例乳腺癌患者的临床病理资料;采用RT-PCR法检测mi R-590在乳腺癌组中的表达量,采用Kaplan-Meier法和Cox回归分析mi R-590与乳腺癌预后的关系。结果:271例乳腺癌患者平均年龄(51. 7±9. 8)岁,中位随访时间为24. 2个月,最长随访时间为75. 8个月; mi R-590高表达组和低表达组绝经人数的差异有统计学意义(P=0. 000),年龄、TNM分期、病理分级、肿瘤大小、HER-2、PR和ER阳性比例以及各分子亚型比例差异无统计学意义(P> 0. 05)。Kaplan-Meier分析显示mi R-590高表达组的DFS和OS要显著低于mi R-590低表达组(P=0. 000和P=0. 015)。Cox回归分析显示mi R-590高表达是影响乳腺癌患者DFS(HR=2. 28,95%CI:1. 54～3. 14,P=0. 000)和OS(HR=2. 18,95%CI:1. 47～3. 48,P=0. 000)的危险因素。结论:mi R-590与乳腺癌患者不良预后有关,是乳腺癌患者不良预后的独立预测因子,可能是乳腺癌治疗的一个靶点。Objective:To assess the relationship between miR-590 and clinicopathological characteristics and prognosis in breast cancer patients.Methods:Clinical data was collected of breast cancer in a certain hospital from 2011 to 2016.RT-PCR was used to detect the miR 590 expression in breast cancer tissue.Kaplan-Meier and cox regression were used to analyse the relationship between miR-590 and prognosis.Results:Mean age of 271 patents was 51.7±9.8 with median follow-up of 24.2 months(max:75.8 months).Significant difference was observed between miR-590 and menopausal status.There was no difference among miR-590 and other parameters.Kaplan-Meier showed that the DFS and OS rate was lower in the low expression group than that in the high expression group(P=0.000,P=0.015).Cox regression indicated that high expression of miR-590 was independently associated with poor DFS and OS status(HR=2.28,95%CI:1.54~3.14,P=0.000;HR=2.18,95%CI:1.47~3.48,P=0.000).Conclusion:High expression of miR-590 was associated with poor prognosis;it was independent predictor and may be treated as a therapy target.

关 键 词：乳腺癌 miRNA-590 生存分析 

分 类 号：R737.9[医药卫生—肿瘤]