盐酸米诺环素与甲硝唑棒治疗牙周炎的效果比较  

Effect comparison of Minocycline Hydrochloride and Metronidazole Sticks in the treatment of periodontitis

作　　者：赫平 HE Ping(Department of Stomatology,Tumor Hospital of Anshan City in Liaoning Province,Anshan 114036,China)

机构地区：[1]辽宁省鞍山市肿瘤医院口腔科,辽宁鞍山114036

出　　处：《中国当代医药》2018年第29期100-102,共3页China Modern Medicine

摘　　要：目的比较盐酸米诺环素与甲硝唑棒治疗牙周炎的临床效果。方法选取我院口腔科2016年8月～2017年8月收治的22例慢性牙周炎患者,按照随机数字表法分为观察组和对照组,各11例。观察组采用盐酸米诺环素软膏治疗,对照组采用甲硝唑棒治疗。比较两组用药前后的牙周临床情况、龈下微生物学情况及用药不良反应发生率。结果两组用药前的牙周临床情况及微生物学情况比较,差异无统计学意义(P>0.05);两组用药7、14 d后的菌斑指数(PLI)、探诊深度(PD)、牙龈指数(GI)、探诊出血(BOP)、杆菌数值、螺旋体数值均低于治疗前,球菌数值高于治疗前,差异有统计学意义(P<0.05)。两组治疗后的临床情况、微生物学情况及不良反应情况比较,差异无统计学意义(P>0.05)。结论盐酸米诺环素与甲硝唑棒均为治疗牙周炎的有效药,具有安全可靠的特性,且两种药物疗效相近。Objective To compare the clinical efficacy of Minocycline Hydrochloride and Metronidazole Sticks in the treatment of periodontitis.Methods Twenty-two patients with chronic periodontitis admitted to our hospital from August 2016 to August 2017 were selected and divided into the observation group and the control group according to the random number table method,11 cases in each group.The observation group was treated with Minocycline Hydrochloride Ointment,and the control group was treated with Metronidazole Sticks.The periodontal clinical conditions,submicron microbiology,and the incidence rate of adverse drug reactions were observed before and after treatment in the two groups.Results there was no significant difference in the clinical and microbiological conditions between the two groups before treatment(P>0.05),and the values of PLI,PD,GI,BOP,the number of bacilli and spirals after treatment at 7,14 d in the two groups were lower than those before treatment,and the number of staphylococci after treatment in the two groups after treatment at 7,14 d was higher than those before treatment(P<0.05).There was no significant difference in clinical situation,microbiology and the incidence rate of adverse reactions between the two groups after treatment(P>0.05).Conclusion Both Minocycline Hydrochloride and Metronidazole Sticks are effective drugs for periodontitis.They have safe and reliable characteristics,and the two drugs have similar efficacy.

关 键 词：盐酸米诺环素软膏 甲硝唑棒 牙周炎 龈下微生物 

分 类 号：R781.42[医药卫生—口腔医学]