微卫星不稳定性的研究进展  

Research progress of microsatellite instability

作　　者：王明建 林惠忠[1] 赵鹏[1] 孟庆海 李思源[1] WANG Ming-jian;LIN Hui-Zhong;ZHAO Peng;MENG Qing-hai;LI Si-yuan(Department of Genteral Surgery,Qingdao Municipal Hospital,Qingdao,Shandong,266071)

机构地区：[1]青岛市市立医院普外科,山东青岛266071

出　　处：《临床普外科电子杂志》2018年第2期35-39,共5页Journal of General Surgery for Clinicians(Electronic Version)

摘　　要：随着分子生物学研究的不断进步,微卫星的状态在结直肠癌(colorectal cancer, CRC)等相关恶性肿瘤中所起的作用也越来越受到重视。具有微卫星不稳定(microsatellite instability,MSI)的CRC具有其独特的分子特征,其临床表现以及预后也有别于一般的散发性CRC,此外一些最新研究表明微卫星状态与一些蛋白的表达相关,这将有可能为具有微卫星不稳定状态的恶性肿瘤提供更新的治疗方案,从而使患者更加受益。With the progress of molecular biology research,the role of microsatellite in colorectal cancer(CRC)and other malignant tumor has also been paid more and more attention.Colorectal cancer with microsatellite instablity(MSI)has its unique molecular characteristics which clinical manifestations and prognosis are also different from the general sporadic colorectal.In addition,some recent studies show that microsatellite status is related to the expression of some proteins,which may provide more benefit from providing new treatment options for patients with MSI-based colorectal cancer.

关 键 词：微星不稳卫定:结直肠癌 治疗 相关蛋白 

分 类 号：R735.2[医药卫生—肿瘤]