中国人群PARK16位点rs947211基因多态性与帕金森病易感性的Meta分析  

ASSOCIATION BETWEEN PARK16 rs947211 POLYMORPHISM AND SUSCEPTIBILITY TO PARKINSON'S DISEASE IN THE CHINESE POPULATION:A META-ANALYSIS

作　　者：辛宗泽 邓文帅[2] 何涛[1] 伦鹏[1] 孙鹏[1] XIN Zongze;DENG Wenshuai;HE Tao;LUN Peng;SUN Peng(Department of Neurosurgery,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院神经外科,山东青岛266003 [2]青岛大学附属医院神经外科监护室,山东青岛266003

出　　处：《精准医学杂志》2018年第5期447-450,453,共5页Journal of Precision Medicine

基　　金：国家自然科学基金面上项目(81470059)

摘　　要：目的探讨中国人群PARK16位点rs947211基因多态性与帕金森病(PD)易感性的关系。方法检索PubMed、Google Scholar、EMBASE、Web of Science、中国知网、维普网以及万方数据知识服务平台等数据库收录的有关于PARK16位点rs947211基因多态性与PD易感性关系的的病例对照研究文献。通过计算优势比(ORs)和相应的95%置信区间(95%CI)评估rs947211基因多态性与PD易感性的关系。结果本次Meta分析共纳入8篇文献(包含11项病例-对照研究),累计患者2 333例,对照组3 064例。Meta分析结果示,rs947211基因多态性可能与中国人群PD的发病风险呈负相关关系(A vs.G:OR=0.80,95%CI=0.74～0.87,P<0.01;AA+AG vs.GG:OR=0.75,95%CI=0.67～0.85,P<0.01;AA vs.GG:OR=0.63,95%CI=0.54～0.74,P<0.01;AG vs.GG:OR=0.80,95%CI=0.70～0.90,P<0.01;AA vs.AG+GG:OR=0.73,95%CI=0.64～0.84,P<0.01)。亚组分析结果示,rs947211基因多态性不仅与降低汉族人群PD发病风险呈负相关关系;也与降低非汉族人群PD发病风险有关。结论 PARK16位点rs947211基因多态性与降低中国人群PD发病风险有关。Objective To investigate the association between PARK16 rs947211 polymorphism and susceptibility to Parkinson’s disease(PD)in the Chinese population.Methods PubMed,Google Scholar,EMBASE,Web of Science,CNKI,VIP,and Wanfang Data were searched for case-control studies on the association between PARK16 rs947211 polymorphism and susceptibility to PD.Odds ratios(OR s)with corresponding 95%confidence intervals(95%CI s)were calculated to evaluate the association between rs947211 polymorphism and susceptibility to PD.Results A total of 8 studies were included in this meta-analysis(with 11 case-control studies),with 2 333 patients in case group and 3 064 in control group.The results of the meta-analysis showed that rs947211 polymorphism was negatively correlated with the risk of PD in the Chinese population(A vs G:OR=0.80,95%CI=0.74-0.87,P<0.01;AA+AG vs GG:OR=0.75,95%CI=0.67-0.85,P<0.01;AA vs GG:OR=0.63,95%CI=0.54-0.74,P<0.01;AG vs GG:OR=0.80,95%CI=0.70-0.90,P<0.01;AA vs AG+GG:OR=0.73,95%CI=0.64-0.84,P<0.01).The subgroup analysis showed that rs947211 polymorphism was negatively correlated with the risk of PD in the Han Chinese population and associated with the reduction in the risk of PD in the non-Han Chinese population.Conclusion PARK16 rs947211 polymorphism may be associated with the reduction in the risk of PD in the Chinese population.

关 键 词：帕金森病 PARK16 rs947211基因 多态性 单核苷酸 Meta分析(主题) 

分 类 号：R742.5[医药卫生—神经病学与精神病学]