注意缺陷多动障碍患儿执行功能和感觉门控功能分析  

Analysis of executive function and sensory gating function in children with attention deficit hyperactivity disorder

作　　者：段敬利[1] 潘伟盟[2] 杜好瑞[1] 穆俊林[1] 朱金富[3] Jing-li Duan;Wei-meng Pan;Hao-rui Du;Jun-lin Mu;Jin-fu Zhu(Department of Neuroelectrophysiology,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453002,China;Department of Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453002,China;Department of Psychology, Xinxiang Medical University,Xinxiang,Henan 453000,China)

机构地区：[1]新乡医学院第二附属医院神经电生理科,河南新乡453002 [2]新乡医学院第二附属医院精神科,河南新乡453002 [3]新乡医学院心理学系,河南新乡453000

出　　处：《中国现代医学杂志》2018年第31期69-73,共5页China Journal of Modern Medicine

基　　金：河南省高等学校重点科研项目支持项目(No:15A190002)

摘　　要：目的探讨注意缺陷多动障碍(ADHD)患儿执行功能和感觉门控功能状况,并分析两者之间的关系。方法 36例符合国际疾病分类第10版(ICD-10)ADHD诊断标准的患儿分别进行威斯康星卡片分类(WCST)测试和听觉click刺激模式ERP-P50检查,并与38例性别、年龄与其匹配的对照组进行对比,同时将患儿WCST各指标与ERP-P50各指标之间进行Pearson相关分析。结果 ADHD患儿组P50 S_1、P50 S_2潜伏期较对照组延长,P50 S_1、(S_1-S_2)波幅、100(1-S_2/S_1)较对照组降低,S_2波幅、S_2/S_1比值较对照组增高,WCST中完成分类数(Cc)、概念化水平(CI%)较对照组降低,错误应答数(Re)、持续错误数(Rpe)、完成第1个分类所需应答数(Rf)较对照组增加,差异有统计学意义(P <0.05);Pearson相关分析得出P50 S_1、P50 S_2潜伏期和P50 S_1波幅与WCST各指标之间无相关性(P>0.05),P50 S_2波幅、S_2/S_1比值与Cc、CI%呈负相关,与Re、Rpe、Rf呈正相关(P <0.05);(S_1-S_2)波幅、100(1-S_2/S_1)与Cc、CI%呈正相关,与RE、Rpe、Rf呈负相关(P <0.05)。结论 ADHD患儿存在执行功能及感觉门控功能的损害,且感觉门控功能损害与执行功能损害之间存在一定的相关性。Objective To explore the status of executive function and sensory gating function in children with attention deficit hyperactivity disorder(ADHD)and analyze the relationship between them.Methods Wisconsin Card Sorting Test(WCST)and auditory click stimulus mode ERP-P50 check were carried out in 36 cases of children who met the criteria for diagnosis of ADHD according with the tenth edition of International Classification of Diseases(ICD-10).The patients were compared with 38 cases in the control group with matching gender and age.At the same time,Pearson correlation analysis was used to analyze the correlations between the indicators of ERP-P50 and WCST.Results The latent periods of P50 S1 and S2 in the ADHD group were longer than those in the control group;and P50 S1,the amplitudes of(S1-S2),and 100(1-S2/S1)were lower than those in the control group;the amplitude of S2 and S2/S1 were higher than those in the control group.The categories completed(Cc)and conceptual level(CI%)of WCST in the ADHD group were lower than those in the control group;the responses errors(Re),responses perseverative errors(Rpe)and response number on the first category(Rf)were higher than those in the control group,the differences were statistically significant(P<0.05).Pearson correlation analysis concluded the latent periods of P50 S1 and S2 and the amplitude of P50 S1 did not have correlations with the indicators of WCST(P>0.05),the amplitude of P50 S2 and S2/S1 had negative correlations with Cc and CI%and positive correlations with Re,Rpe and Rf(P<0.05);the amplitudes of(S1-S2)and 100(1-S2/S1)had positive correlations with Cc and CI%and negative correlations with Re,Rpe and Rf(P<0.05).Conclusions Children with ADHD have damages of executive function and sensory gating function and there are certain correlations between the damages of them.

关 键 词：注意缺陷多动障碍 执行功能 感觉门控功能 

分 类 号：R749[医药卫生—神经病学与精神病学]