LncRNA-ATB在肿瘤中的表达及调控作用研究  

Expression of lncRNA-ATB and its regulatory mechanisms in carcinomas

作　　者：姜兴明[1] 苏志雷[1] 康鹏程[1] 李春龙[1] 崔云甫[1] Xing-ming Jiang;Zhi-lei Su;Peng-cheng Kang;Chun-long Li;Yun-fu Cui(Department of Hepatopancreatobiliary Surgery,the Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院胆胰外科,黑龙江哈尔滨150086

出　　处：《中国现代医学杂志》2018年第32期51-56,共6页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:81602088);中国博士后科学基金(No:2017M621305);黑龙江省博士后科学基金(No:LBH-Z16096);黑龙江省卫生计生委科研课题(No:2016-049)

摘　　要：长链非编码RNA(lncRNA)是长度>200 nt非编码RNA家族中的重要成员。随着研究的不断深入,人体恶性肿瘤内异常表达的lncRNA对肿瘤发生、发展所起到的调控作用正逐渐被认知。被转化生长因子b激活的长链非编码RNA(lncRNA-ATB)在诸多肿瘤中呈现异常表达,并能够调控肿瘤增殖、侵袭转移、抗凋亡及耐药等恶性生物学行为。Long non-coding RNA(lncRNA),which has the length of more than 200 nt,is an important member of ncRNA family.With the progression of lncRNA researches,it has been recognized that the dysregulated lncRNAs play important regulatory roles in the occurrence and progression of many human malignant tumors.It has been found that transforming growth factorβ-activated lncRNA(lncRNA-ATB)is dysregulated in various cancers and could regulate the malignant biological behaviors including proliferation,invasion,anti-apoptosis,metastasis and drug-resistance.The expression and regulatory effect of lncRNA-ATB in neoplasms will be summarized in this article.

关 键 词：长链非编码RNA 被转化生长因子b激活的长链非编码RNA 表达 调控作用 

分 类 号：R73[医药卫生—肿瘤]