保留膀胱手术联合动脉插管化疗对高危非肌层浸润性膀胱癌患者的疗效及CD3^+CD8^+细胞水平的影响  

Effect of bladder-sparing surgery and chemotherapy via arterial catheterization on efficacy and CD3^+ and CD8^+ levels in patients with high-risk non-muscle invasive bladder cancer

作　　者：刘建武[1] 魏淑青[2] Liu Jianwu;Wei Shuqing(Department of Urology,Shanxi Provincial Cancer Hospital,Taiyuan 030013,China)

机构地区：[1]山西省肿瘤医院泌尿外科,太原030013 [2]山西省肿瘤医院老年病科,太原030013

出　　处：《中国药物与临床》2018年第11期1898-1900,共3页Chinese Remedies & Clinics

摘　　要：目的研究保留膀胱手术联合动脉插管化疗对高危非肌层浸润性膀胱癌患者的疗效及CD3^+、CD8^+水平的影响。方法 2012年7月至2014年7月我院68例高危非肌层浸润性膀胱癌患者就诊,且均给予保留膀胱手术进行治疗。以数字法随机分成观察组(34例)和对照组(34例)。观察组给予动脉插管化疗,对照组给予膀胱灌注,随访观察2组患者的临床疗效、不良反应、复发与病死率及免疫功能。结果观察组总有效率76%(26/34)显著高于对照组32%(11/34);治疗后观察组不良发应率20%(7/34)显著低于对照组74%(25/34);治疗后观察组复发率20%(7/34)显著低于对照组56%(19/34),观察组癌性死亡6%(2/34)显著低于对照组26%(9/34);治疗后观察组患者CD3^+显著高于对照组,观察组CD8^+显著低于对照组,差异均有统计学意义(均P<0.05)。结论保留膀胱手术联合动脉插管化疗对高危NMIBC患者治疗的疗效显著,且不良发应以及复发与病死率低,还能改善患者免疫功能,值得临床推广。Objective To investigate the effect of bladder-sparing surgery and chemotherapy via arterial catheterization on the efficacy and CD3+and CD8+levels in patients with high-risk non-muscle invasive bladder can-cer(NMIBC).Methods Sixty-eight patients with high-risk NMIBC admitted to our hospital between July 2012 and July 2014 were included in the study and treated with bladder-sparing surgery.All patients were randomly divided in-to the study group(n=34)and control group(n=34).The study group was given chemotherapy via arterial catheterization,and the control group was given bladder irrigation.The clinical efficacy,adverse reactions,recurrence and mortality rates,and immune function in the two groups were followed up.Results The total effective rate in the study group was significantly higher than that in the control group[76%(26/34)vs 32%(11/34)].After the treatment,the incidenceof adverse reactions in the study group was significantly lower than that in the control group[20%(7/34)vs.74%(25/34)].After the treatment,the recurrence rate in the study group was significantly lower than that in the control group[20%(7/34)vs 56%(19/34)],and the cancer-induced mortality rate in the study group was significantly lower than that in the control group[6%(2/34)vs 26%(9/34)].After the treatment,the CD3+level in the study group was significantly higher than that in the control group,whereas the CD8+level in the study group was significantly lower than that in the control group,with statistically significant differences(all P<0.05).Conclusion Bladder-sparing surgery and chemotherapy via arterial catheterization is effective in the treatment of high-risk NMIBC patients with low incidence of adverse reactions and low recurrence and mortality rates.It may improve the immune function of patients,which justifies its widespread use in the clinical settings.

关 键 词：膀胱肿瘤 保留膀胱手术 动脉插管化疗 

分 类 号：R737.14[医药卫生—肿瘤]