应用抑郁症状快速评定量表评估抑郁症患者急性期治疗后残留症状的性别差异  

Using the Quick Inventory of Depressive Symptomatology to assess gender differences in residual symptoms of depressed patients after acute phase treatment

作　　者：赵娜[1] 王晓红[1] 师晶晶 丰雷 朱雪泉 王刚 胡建[1] ZHAO Na;WANG Xiaohong;SHI Jingjing;FENG Lei;ZHU Xuequan;WANG Gang;HU Jian(Department of Psychiatry,First Affiliated Hospital of Harbin Medical University,Harbin 150000,China;The First Specialized Subject Hospital of Harbin,Harbin 150000,China;The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders&Beijing Anding Hospital,Capital Medical University,Beijing 100008,China)

机构地区：[1]哈尔滨医科大学附属第一医院精神科,哈尔滨150000 [2]哈尔滨市第一专科医院,哈尔滨150000 [3]首都医科大学附属北京安定医院抑郁症治疗中心,国家精神心理疾病临床医学研究中心,北京脑重大疾病研究院抑郁症研究所,北京100008

出　　处：《中国心理卫生杂志》2018年第11期903-909,共7页Chinese Mental Health Journal

基　　金：国家科技支撑计划(2015BAI13B03);北京市卫生系统高层次卫生技术人才培养项目(2013-2-001)。

摘　　要：目的:探讨抑郁症患者急性期治疗后残留症状的性别差异、残留症状与治疗时间和治疗方式的关系。方法:选择符合ICD-10抑郁发作或复发性抑郁障碍诊断标准的门诊抑郁症急性期治疗后患者1503例(男性559例,女性944例),此次抑郁发作已治疗8～12周,应用抑郁症状快速评定量表(QIDS)评估分为残留症状组(n=733)和无残留症状组(n=770),比较残留症状与治疗时间(8～12周)、药物治疗(单种抗抑郁药物治疗、联合治疗)之间的性别差异。结果:男性残留症状总分、感觉沮丧、反应迟钝得分高于女性,夜间睡眠得分低于女性(均P <0. 05)。治疗11周男性的残留症状数目多于女性;随治疗时间增加,女性残留症状数目减少(P <0. 05),残留症状轻度比例高于中度及以上(P <0. 05)。使用单种抗抑郁药物治疗,男性残留症状中度及以上比例高于女性(P <0. 05);女性联合两种及以上抗抑郁药物残留症状中度及以上所占比例高于使用单种抗抑郁药物(P <0. 05)。结论:抑郁症患者急性期治疗后残留症状存在性别差异,不同治疗时间和治疗方式对残留症状有影响。Objective:To investigate gender differences in residual symptoms in patients with depression after acute phase treatment and explore the relationship between residual symptoms and treatment time as well as treatment modalities.Methods:Totally 1503 outpatients(559 males and 944 females)diagnosed as depressive episode or recurrent depressive disorder with the International Statistical Classification of Diseases and Related Health Problems,Tenth Revision(ICD-10)after acute phase treatment were enrolled in this study.This depressive episode had been treated for 8 to 12 weeks.The patients were divided into the residual symptoms group(733 cases)and the non-residual symptoms group(770 cases)with the Quick Inventory of Depressive Symptomatology scales(QIDS).Gender differences in residual symptoms,different treatment(8-12 weeks)and the treatment method(single antidepressant drug therapy and combination therapy)were analyzed.Results:The total scores of residual symptoms,the"feeling depression"and"slow reaction"items were higher in males than in females,while the scores of"sleep during the night"were lower in males(Ps<0.05).In patients with 11-week treatment,the numbers of residual symptoms were more in males than in females.In females,with the increasing of treatment time,the number of residual symptoms showed decreasing(P<0.05),the mild proportion of residual symptoms was higher than that of moderate or above(P<0.05).With single antidepressant drug,in males the moderate or above proportion of residual symptoms were higher than in females(P<0.05).The moderate or above proportion of residual symptoms in the combination of two or more antidepressants was higher than that of single antidepressant drug in females(P<0.05).Conclusion:There are gender differences in residual symptoms of depressed patients after acute phase treatment,different treatment time and treatment methods have an effect on the residual symptoms.

关 键 词：抑郁症 残留症状 性别差异 QIDS 治疗 

分 类 号：R749.41[医药卫生—神经病学与精神病学]