Risk factors for liver disease among adults of Mexican descent in the United States and Mexico  

作　　者：Yvonne N Flores Zuo-Feng Zhang Roshan Bastani Mei Leng Catherine M Crespi Paula Ramírez-Palacios Heather Stevens Jorge Salmerón 

机构地区：[1]Unidad de Investigación Epidemiológica y en Servicios de Salud,Delegación Morelos,Instituto Mexicano del Seguro Social,Cuernavaca,Morelos 62000,México [2]UCLA Department of Health Policy and Management and Kaiser Permanente Center for Health Equity,Fielding School of Public Health,Los Angeles,CA 90095,United States [3]UCLA Cancer Prevention and Control Research Center,Fielding School of Public Health and Jonsson Comprehensive Cancer Center,Los Angeles,CA 90095,United States [4]UCLA Division of General Internal Medicine and Health Services Research,Los Angeles,CA 90095,United States [5]UCLA Department of Biostatistics,Fielding School of Public Health,Los Angeles,CA 90095,United States [6]University of Washington,School of Medicine,Seattle,WA 98195,United States [7]Universidad Nacional Autónoma de México,Academic Epidemiology Research Unit,Avenida Universidad 3000,Ciudad Universitaria,Coyoacán,Mexico City 04510,México [8]Centro de Investigación en Salud Poblacional,Instituto Nacional de Salud Pública,Cuernavaca,Morelos 62100,México

出　　处：《World Journal of Gastroenterology》2018年第37期4281-4290,共10页世界胃肠病学杂志（英文版）

基　　金：Supported by the Programa de Investigación en Migracion y Salud(PIMSA),No.2015-2106;the Instituto Mexicano del Seguro Social(IMSS),No.2005/1/Ⅰ/093;and the Consejo Nacional de Ciencia y Tecnología(CONACYT),No.26267M;No.SALUD-2011-01-161930;the NIH,No.UL1TR000124 to Crespi CM,and NIH/NCI No.K07CA197179 to Flores YN

摘　　要：AIM To compare the prevalence of chronic liver disease(CLD) risk factors in a representative sample of MexicanAmericans born in the United States(US) or Mexico, to a sample of adults in Mexico.METHODS Data for Mexican-Americans in the US were obtained from the 1999-2014 National Health and Nutrition Examination Survey(NHANES), which includes persons of Mexican origin living in the US(n = 4274). The NHANES sample was restricted to Mexican-American participants who were 20 years and older, born in the US or Mexico, not pregnant or breastfeeding, and with medical insurance.The data in Mexico were obtained from the 2004-2013 Health Worker Cohort Study in Cuernavaca, Mexico(n =9485). The following known risk factors for liver disease/cancer were evaluated: elevated aminotransferase levels(elevated alanine aminotransferase was defined as > 40 IU/L for males and females; elevated aspartate aminotransferase was defined as > 40 IU/L for males and females), infection with hepatitis B or hepatitis C,metabolic syndrome, high total cholesterol, diabetes,obesity, abdominal obesity, and heavy alcohol use. The main independent variables for this study classified individuals by country of residence(i.e., Mexico vs the US) and place of birth(i.e., US-born vs Mexico-born).Regression analyses were used to investigate CLD risk factors.RESULTS After adjusting for socio-demographic characteristics,Mexican-American males were more likely to be obese,diabetic, heavy/binge drinkers or have abdominal obesity than males in Mexico. The adjusted multivariate results for females also indicate that Mexican-American females were significantly more likely to be obese, diabetic, be heavy/binge drinkers or have abdominal obesity than Mexican females. The prevalence ratios and prevalence differences mirror the multivariate analysis findings for the aforementioned risk factors, showing a greater risk among US-born as compared to Mexico-born MexicanAmericans. CONCLUSION In this study, Mexican-Americans in the US had more risk factors for CLD than theiAIM To compare the prevalence of chronic liver disease(CLD) risk factors in a representative sample of MexicanAmericans born in the United States(US) or Mexico, to a sample of adults in Mexico.METHODS Data for Mexican-Americans in the US were obtained from the 1999-2014 National Health and Nutrition Examination Survey(NHANES), which includes persons of Mexican origin living in the US(n = 4274). The NHANES sample was restricted to Mexican-American participants who were 20 years and older, born in the US or Mexico, not pregnant or breastfeeding, and with medical insurance.The data in Mexico were obtained from the 2004-2013 Health Worker Cohort Study in Cuernavaca, Mexico(n =9485). The following known risk factors for liver disease/cancer were evaluated: elevated aminotransferase levels(elevated alanine aminotransferase was defined as > 40 IU/L for males and females; elevated aspartate aminotransferase was defined as > 40 IU/L for males and females), infection with hepatitis B or hepatitis C,metabolic syndrome, high total cholesterol, diabetes,obesity, abdominal obesity, and heavy alcohol use. The main independent variables for this study classified individuals by country of residence(i.e., Mexico vs the US) and place of birth(i.e., US-born vs Mexico-born).Regression analyses were used to investigate CLD risk factors.RESULTS After adjusting for socio-demographic characteristics,Mexican-American males were more likely to be obese,diabetic, heavy/binge drinkers or have abdominal obesity than males in Mexico. The adjusted multivariate results for females also indicate that Mexican-American females were significantly more likely to be obese, diabetic, be heavy/binge drinkers or have abdominal obesity than Mexican females. The prevalence ratios and prevalence differences mirror the multivariate analysis findings for the aforementioned risk factors, showing a greater risk among US-born as compared to Mexico-born MexicanAmericans. CONCLUSION In this study, Mexican-Americans in the US had more risk factors for CLD than thei

关 键 词：Liver disease Risk factors Health DISPARITIES Mexico MEXICAN AMERICANS Latinos 

分 类 号：R57[医药卫生—消化系统]