静息态fMRI观察遗忘型轻度认知障碍患者长-短程功能连接  

Resting-state fMRI observation on changes of long-short functional connectivity in amnestic mild cognitive impairment patients

作　　者：闫少珍 齐志刚[1,2] 安彦虹[1,2] 张默[1,2] 卢洁[1,2,3] YAN Shaozhen;QI Zhigang;AN Yanhong;ZHANG Mo;LU Jie(Department of Radiology,Capital Medical University,Beijing 100053,China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics,Beijing 100053,China;Department of Nuclear Medicine,Xuanwu Hospital, Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院放射科,北京100053 [2]首都医科大学宣武医院核医学科,北京100053 [3]磁共振成像脑信息学北京市重点实验室,北京100053

出　　处：《中国医学影像技术》2018年第11期1604-1609,共6页Chinese Journal of Medical Imaging Technology

基　　金：国家重点研发计划(2016YFC0107107);国家自然科学基金优秀青年科学基金项目(81522021);北京市医管局人才培养计划"登峰"项目(DFL20180802);北京市科学技术计划(Z171100000117001)

摘　　要：目的分析遗忘型轻度认知障碍(aMCI)患者长、短程功能连接的变化。方法采集37例aMCI患者(aMCI组)和40名认知功能正常志愿者(对照组)的静息态fMRI数据,以GRETNA软件自动计算完成全脑长程和短程功能连接,比较2组间差异。结果与对照组比较,aMCI组长程功能连接减低的脑区主要位于双侧楔前叶/中后扣带回、右侧中央沟盖,长程功能连接增强的脑区主要分布于双侧中央前回、左侧颞极/颞中回、左侧直回、右侧眶内额上回、左侧眶内额下回;其短程功能连接减低脑区位于左侧岛叶,短程功能连接增强脑区主要包括左侧颞极/颞上回、左侧颞中回、左侧直回、左侧眶内额下回、右侧海马、右侧颞上回、右侧额中回、右侧辅助运动区及左侧中央后回/楔前叶。结论 aMCI组患者脑长、短程功能连接模式均有所改变,有助于理解aMCI患者脑网络改变的病理生理机制。Objective To explore the long and short range functional connectivity in amnestic mild cognitive impairment(aMCI)patients using resting-state fMRI.Methods Totally 37 aMCI patients(aMCI group)and 40 volunteers with normal cognitive function(control group)underwent resting-state fMRI.GRETNA software was used for data processing to obtain the long and short range functional connectivity maps,then the functional connectivity was compared between the 2 groups.Results Compared with the control group,aMCI patients showed decreased long-range functional connectivity in the bilateral precuneus/middle posterior cingulate cortex and right rolandic,while increased long-range functional connectivity in bilateral precentral gyrus,left temporal pole/middle temporal gyrus,left rectus gyrus,right superior frontal gyrus and left inferior frontal gyrus;the decreased short-range functional connectivity of aMCI patients located in the left insula lobe,while increased short-range functional connectivity located in left temporal pole/superior temporal gyrus,left middle temporal gyrus,left rectus gyrus,left inferior frontal gyrus,right hippocampus,right superior temporal gyrus,right middle frontal gyrus,right supplementary motor area and left postcentral gyrus/precuneus.Conclusion The short and long-range functional connections of aMCI patients are changed,which might be helpful to understanding of the disrupted neural network of aMCI.

关 键 词：遗忘 认知障碍 静息态 磁共振成像 功能连接 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]