^(18)F-FDG及^(18)F-FP-DTBZ双示踪PET/CT显像诊断帕金森病  

^(18)F-FDG and ^(18)F-FP-DTBZ PET/CT imaging in diagnosis of Parkinson disease

作　　者：尚琨[1] 乔洪文[1] 卢洁[1,2,3] 崔碧霄 苏玉盛[1] 李则[1] 梁志刚[1] SHANG Kun;QIAO Hongwen;LU Jie;CUI Bixiao;SU Yusheng;LI Ze;LIANG Zhigang(Department of Nuclear Medicine,Xuanwu Hospital, Capital Medical University,Beijing 100053,China;Department of Radiology,Xuanwu Hospital, Capital Medical University,Beijing 100053,China;China;3.Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院核医学科 [2]首都医科大学宣武医院放射科 [3]磁共振成像脑信息学北京市重点实验室

出　　处：《中国医学影像技术》2018年第11期1615-1620,共6页Chinese Journal of Medical Imaging Technology

基　　金：十三五国家重点研发项目(2016YFC0103000)

摘　　要：目的探讨^(18)F-FDG及^(18)F-FP-DTBZ双示踪PET/CT显像诊断帕金森病(PD)的价值。方法对28例PD患者(PD组)和10名健康志愿者(对照组)行^(18)F-FDG脑代谢和^(18)F-FP-DTBZ PET/CT显像。对PD患者采用PD统一评分量表第Ⅲ部分(UPDRSⅢ)和Hoehn-Yahr(H-Y)进行临床评分。在^(18) F-FDG PET图像上观察代谢减低脑区;在^(18) F-FPDTBZ PET图像上测得尾状核、壳核前部及壳核后部标准摄取值(SUV)。比较PD组与对照组间的差异,并与临床评分进行相关性分析。结果 PD组中23例(23/28,82.14%)大脑皮层代谢减低,8例(8/28,28.57%)基底核代谢减低。PD组尾状核^(18)F-FP-DTBZ SUV与对照组差异无统计学意义(P=0.1^(18)),壳核前部及后部SUV均低于对照组(P均<0.01)。PD组早期PD患者尾状核^(18) F-FP-DTBZ SUV与对照组差异无统计学意义(P>0.05),壳核前部及后部^(18) F-FPDTBZ SUV均低于对照组(P均<0.01);中晚期PD患者尾状核、壳核前部及后部^(18) F-FP-DTBZ SUV均低于对照组(P均<0.05)。壳核前部及后部^(18)F-FP-DTBZ SUV均与UPDRSⅢ运动评分、H-Y分期均呈负相关(壳核前部:r=-0.463、-0.564,P=0.002、0.001;壳核后部:r=-0.412、-0.585,P=0.005、0.001)。单侧肢体症状PD患者症状对侧壳核前部及后部^(18)F-FP-DTBZ SUV较症状侧减低(P均<0.05)。结论 ^(18) F-FDG及^(18) F-FP-DTBZ双示踪PET/CT显像可为诊断PD和评估病情提供有益信息。Objective To explore the value of 18 F-FDG and 18 F-FP-DTBZ PET/CT imaging in diagnosis of Parkinson disease(PD).Methods Totally 28 PD patients(PD group)and 10 healthy controls(control group)were recruited.Brain 18 F-FDG and 18 F-FP-DTBZ PET/CT were performed.The unified Parkinson disease rating scale motor score partⅢ(UPDRSⅢ)and Hoehn-Yahr(H-Y)scale were used to evaluate the clinical state.The regions with hypometabolism were found on 18 F-FDG PET images,and the standard uptake value(SUV)of caudate nuclei,anterior and posterior putamen were acquired on 18 F-FP-DTBZ PET images and compared between the two groups,the correlation of SUV with UPDRSⅢand H-Y scores was evaluated.Results In PD group,the hypometabolism of 18 F-FDG at cortex was found in 23 patients(23/28,82.14%)and at basal ganglia in 8(8/28,28.57%).There was no significant difference of 18 F-FP-DTBZ SUV at caudate nuclei between the two groups(P=0.118).SUV at anterior and posterior putamen decreased significantly compared with control group(both P<0.01).Compared with control group,18 F-FP-DTBZ SUV at caudate nuclei had no significant difference(P>0.05),while SUV at anterior and posterior putamen decreased in early-stage PD patients of PD group(both P<0.01).Among advanced stage PD patients of PD group,SUV at caudate nuclei,anterior and posterior putamen were all lower than those in control group(all P<0.05).18 F-FP-DTBZ SUV in anterior and posterior putamen showed obvious negative correlation with UPDRSⅢand H-Y scores(anterior putamen:r=-0.463,-0.564,P=0.002,0.001;posterior putamen:r=-0.412,-0.585,P=0.005,0.001).In PD patients with unilateral symptoms,18 F-FP-DTBZ SUV decreased at the contralateral anterior and posterior putamen than at ipsilateral putamen(both P<0.05).Conclusion 18 F-FDG and 18 F-FP-DTBZ PET/CT imaging can provide useful information in diagnosis and evaluation of PD patients.

关 键 词：帕金森病 氟脱氧葡萄糖F18 Ⅱ型囊泡单胺转运体 体层摄影术 发射型计算机 

分 类 号：R742[医药卫生—神经病学与精神病学] R817.4[医药卫生—临床医学]