经阴道实时超声弹性成像诊断宫颈癌:Meta分析  

Diagnostic value of transvaginal real-time ultrasound elastography for cervical cancer:Meta-analysis

作　　者：尹盼盼 李井平 王少春[2] 陈东风[2] YIN Panpan;LI Jingping;WANG Shaochun;CHEN Dongfeng(School of Clinical Medicine,Jining Medical College,Jining 272000,China;Department of Ultrasound,the Affiliated Hospital of Jining Medical School, Jining 272000,China)

机构地区：[1]济宁医学院临床医学院,山东济宁272000 [2]济宁医学院附属医院超声科,山东济宁272000

出　　处：《中国医学影像技术》2018年第11期1681-1685,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的采用Meta分析评价经阴道实时超声弹性成像技术诊断宫颈癌的价值。方法检索PubMed、Embase、中国知网、万方及维普数据库,按照纳入及排除标准筛选文献,并提取四格表数据。采用STATA 12.0软件检验异质性并进行统计学分析,选择相应效应模型,合并其效应量(敏感度、特异度),绘制综合ROC曲线,并计算AUC。结果最终纳入25篇文献,包含2 303例患者。经阴道实时超声弹性成像诊断宫颈癌汇总敏感度、特异度、阳性似然比、阴性似然比及诊断比值比分别为0.85[95%CI(0.82,0.88)]、0.88[95%CI(0.83,0.92)]、7.40[95%CI(4.80,11.30)]、0.17[95%CI(0.13,0.21)]和44[95%CI(24,82)],AUC为0.92[95%CI(0.89,0.94)]。回归分析显示异质性来源可能与弹性评分截断值有关。结论经阴道实时超声弹性成像技术对宫颈癌有较高的诊断价值。Objective To investigate the value of transvaginal real-time elastography in the diagnosis of cervical cancer with Meta-analysis.Methods A systematic search was conducted in PubMed,Embase,CNKI,Wanfang and VIP databases.The literatures were screened according to inclusion and exclusion criteria,and four tabular data were extracted.With Meta Disc version STATA 12.0 software,statistical analysis was performed,and heterogeneity of the included articles was tested.Based on the results of heterogeneity test,proper effect model was selected to calculate the pooled sensitivity and specificity.Summary ROC curve was obtained,and AUC was calculated.Results A total of 25 literatures were enrolled,including 2 303 patients.The pooled sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and diagnostic odds ratio for transvaginal real-time elastography in the diagnosis of cervical cancer was 0.85(95%CI[0.82,0.88]),0.88(95%CI[0.83,0.92]),7.40(95%CI[4.80,11.30]),0.17(95%CI[0.13,0.21])and 44(95%CI[24,82]),while AUC was 0.92(95%CI[0.89,0.94]),respectively.Regression analysis revealed that the heterogeneity might result from the elastic score cutoff.Conclusion Transvaginal real-time elastography has good diagnostic value in diagnosis of cervical cancer.

关 键 词：宫颈肿瘤 荟萃分析 超声检查 弹性成像技术 

分 类 号：R737.33[医药卫生—肿瘤] R445.1[医药卫生—临床医学]