多西紫杉醇、顺铂、氟尿嘧啶三药联合在转移鼻咽癌二线治疗中的临床分析  

Clinical analysis of combination of docetaxel, cisplatin and fluorouracil in second line treatment of metastatic nasopharyngeal carcinoma

作　　者：黄琳[1] 杨力宝[1] 黄松华[1] HUANG Lin;YANG Li-bao;HUANG Song-hua(Second Hospital of Sanming City(Fifth College of Clinical Medicine,Fujian University of Traditional Chinese Medicine),Sanming 366000,China)

机构地区：[1]三明市第二医院(福建中医药大学第五临床医学院),福建三明366000

出　　处：《中国医药指南》2018年第31期10-11,共2页Guide of China Medicine

摘　　要：目的评价多西紫杉醇、顺铂、氟尿嘧啶三药联合对转移晚期鼻咽癌的二线治疗疗效及其不良反应,探讨治疗鼻咽癌的二线化疗方案。方法诊断明确放疗后转移的晚期鼻咽癌患者13例,多西他赛50 mg/m^2 d1+顺铂50 mg/m^2 d1-5+5-FU 500 mg/(m^2·d) d1-5,每3周重复。化疗2个周期后根据RECTST1.1(Response Evaluation Criteria in Solid Tumors1.1)效评价标准和通用不良事件术语标准v4.0(Common Toxicity Criteria Version 4.0)评价系统分级(0～Ⅳ)评价疗效和不良反应。结果 13例患者共完成46个周期化疗,每例患者化疗周期数1～4个,中位化疗周期数为3个。完全缓解(CR)3例,部分缓解(PR)6例,稳定(SD)2例,进展(PD)2例,客观缓解率(ORR)为69%。1年生存率为84.6%(11/13)。不良反应主要表现为脱发,粒细胞和血小板、血色素中轻度减少,其余不良反应较少。结论多西紫杉醇联合顺铂、氟尿嘧啶治疗远处转移鼻咽癌有效率高,不良反应可以耐受,是治疗晚期鼻咽癌较好的二线化疗方案。Objective To evaluate the effectiveness and side effects of the combination of docetaxel and cisplatin,5-FU in the treatment of metastatic nasopharyngeal carcinoma.Methods Thirteen patients with metastatic nasopharyngeal carcinoma after treatment were enrolled.The treatment regimen include docetaxel 50 mg/m2 d1,cisplatin 50 mg/m^2 d1,5-FU 500 mg/(m^2.d)d1-5.Cycles were repeated every 3 weeks.The treatment effects were evaluated by RECTST1.1 criterion every 2 cycles and toxicities were evaluated by Common Toxicity Criteria(CTC)Version 4.0.Results Totally 46 cycles of chemotherapy were conducted in 13 patients.Patient received 1-4 cycles with average of 3 cycles.Complete response(CR)was observed in 3 patients,Partial response(PR)in 6 patients,Stable disease(SD)in 2 patients and Progression disease(PD)in 2 patients result in objective response rate of 69%(9/13)and 1 year survival rate of 84.6%(11/13).The main toxicity were mild alopecia,neutropenia,thrombocytopenia and anemia.Other tixicities were very rare.Conclusion Combination of docetaxel and cisplatin,5-F U is an effective regimen in the treatment of metastatic and recurrent nasopharyngeal carcinoma.It's an effective and tolerable second-line chemotherapy.

关 键 词：鼻咽癌 药物疗法 多西他赛 顺铂 氟尿嘧啶 治疗应用 

分 类 号：R739.63[医药卫生—肿瘤]