马来酸曲美布汀联合文拉法辛治疗功能性消化不良的疗效观察及对胃容受性和胃肠激素水平的影响  

Efficacy of trimebutine maleate combined with venlafaxine in treatment of functional dyspepsia: Impact on gastric tolerance and gastrointestinal hormone levels

作　　者：孙寿广 江冬莲 Shou-Guang Sun;Dong-Lian Jiang(Department of Gastroenterology,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430077,Hubei Province,China;Department of Gastroenterology,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430077,Hubei Province,China)

机构地区：[1]天津市宁河区医院内科,天津市301500 [2]华中科技大学同济医学院附属梨园医院消化内科,湖北省武汉市430077

出　　处：《世界华人消化杂志》2018年第32期1901-1906,共6页World Chinese Journal of Digestology

摘　　要：目的评价马来酸曲美布汀片联合文拉法辛缓释片治疗功能性消化不良(functional dyspepsia, FD)的疗效及其对胃容受性及胃肠激素含量的影响.方法选择2017-01/2018-01于天津市宁河区医院门诊确诊的FD患者130例,采用随机数字表法将患者分为对照组和观察组,每组各65例.对照组患者给予马来酸曲美布汀片口服;观察组在对照组基础上,联合文拉法辛缓释片治疗.两组患者均治疗4 wk后评价疗效.比较两组患者的临床症状积分、临床总有效率、焦虑自评量表(self-rating anxiety scale, SAS)、抑郁自评量表(self-rating depression scale, SDS)评分、不良反应发生率、胃动素(motilin, MOT)、生长抑素(somatostatin SS)、胃泌素(gastrin,GAS).检测并比较两组患者胃电图、胃容受性、胃肠激素指标变化.结果治疗后,观察组患者的各项症状积分显著低于对照组(P<0.05).观察组的临床总有效率为100%(65/65),显著高于对照组的86.2%(57/65)(χ2=5.097, P <0.01).治疗后,观察组患者的SAS评分和SDS评分显著低于对照组(P<0.05).且两组患者不良反应发生率比较差异无统计学意义(P>0.05).治疗后,两组患者的主频、慢波频率及最大饮水量均较治疗前显著增加(P<0.05),且治疗后观察组患者的上述指标显著高于对照组(P<0.05).治疗后,两组患者的MOT及SS含量均显著降低,GAS显著增高(P <0.05),且治疗后观察组患者的MOT及SS含量显著低于对照组,GAS显著高于对照组(P <0.05).结论马来酸曲美布汀片联合文拉法辛缓释片治疗可有效缓解FD患者腹痛、腹胀、恶心等胃肠道症状,并改善患者焦虑抑郁状态,临床安全有效.AIM To evaluate the efficacy of trimebutine maleate combined with venlafaxine in the treatment of functional dyspepsia(FD)and the effect on gastric receptivity and gastrointestinal hormone levels.METHODS One hundred and thirty patients with FD diagnosed at Tianjin Ninghe District Hospital from January 2017 to January 2018 were randomly divided into an observation group and a control group,with 65 cases in each group.Both groups were given oral trimebutine maleate tablets,and the observation group was additionally given venlafaxine sustained-release tablets.Both groups were evaluated for efficacy after 4 wk of treatment.The clinical symptom score,clinical total effective rate,selfrating anxiety scale(SAS)score,self-rating depression scale(SDS)score,adverse reaction rate,motilin(MOT),somatostatin(SS),gastrin(GAS),and the incidence of adverse reactions were compared between the two groups.The changes of electrocardiogram,gastric tolerance,and gastrointestinal hormones were measured and compared between the two groups.RESULTS After treatment,the symptom score of patients in the observation group was significantly lower than that of the control group(P<0.05).The total effective rate was 100%(65/65)in the observation group,which was significantly higher than that in the control group(86.2%,57/65;χ2=5.097,P<0.01).The scores of SAS and SDS in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The frequency and low frequency of electrogastrogram and maximum drinking water quantity of the two groups were significantly higher than those before treatment(P<0.05),and these indicators were significantly higher in the observation group than in the control group(P<0.05).After treatment,MOT and SS levels were significantly decreased in both groups,and GAS was significantly increased(P<0.05).The levels of MOT and SS in the observation group were significantly lower than those in the control

关 键 词：马来酸曲美布汀片 文拉法辛缓释片 功能性消化不良 疗效分析 

分 类 号：R57[医药卫生—消化系统]