Ampulla of Vater carcinoma: Molecular landscape and clinical implications  

作　　者：Antonio Pea Giulio Riva Riccardo Bernasconi Elisabetta Sereni Rita Teresa Lawlor Aldo Scarpa Claudio Luchini 

机构地区：[1]Department of Surgery, University and Hospital Trust of Verona [2]Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona [3]ARC-Net Research Center, University and Hospital Trust of Verona

出　　处：《World Journal of Gastrointestinal Oncology》2018年第11期370-380,共11页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Supported by the Italian Association for Cancer Research,No.12182

摘　　要：Ampulla of Vater is a peculiar anatomical structure, characterized by the crossroad of three distinct epithelia: Intestinal, ductal pancreatic and biliary. Adenocarcinomas arising in this area represent an opportunity to understand the comparative biology of all periampullary malignancies. These neoplasms can exhibit intestinal, pancreaticobiliary or mixed features, whereas the subclassification based on morphology and immunohistochemical features failed in demonstrating a robust prognostic reliability. In the last few years, the molecular landscape of this tumor entity has been uncovered, identifying alterations that may serve as prognostic and predictive biomarkers. In this review, the histological and genetic characteristics of ampullary carcinomas are discussed, taking into account the main clinical and therapeutic implications related to this tumor type as well.Ampulla of Vater is a peculiar anatomical structure, characterized by the crossroad of three distinct epithelia: Intestinal, ductal pancreatic and biliary. Adenocarcinomas arising in this area represent an opportunity to understand the comparative biology of all periampullary malignancies. These neoplasms can exhibit intestinal, pancreaticobiliary or mixed features, whereas the subclassification based on morphology and immunohistochemical features failed in demonstrating a robust prognostic reliability. In the last few years, the molecular landscape of this tumor entity has been uncovered, identifying alterations that may serve as prognostic and predictive biomarkers. In this review, the histological and genetic characteristics of ampullary carcinomas are discussed, taking into account the main clinical and therapeutic implications related to this tumor type as well.

关 键 词：Pancreatobiliary INTESTINAL Mixed ELF3 TP53 KRAS Ampullary VATER Histotype 

分 类 号：R[医药卫生]