催产素对早发性精神分裂症患者心理理论及共情能力的影响  

Effect of intranasal oxytocin on theory of mind and empathy in early onset schizophrenic patients

作　　者：江小英[1] 祝一虹 赵勇[1] 朱丞[1] 许子明[1] JIANG Xiaoying;ZHU Yihong;ZHAO Yong(Department of Psychiatry,Hangzhou Seventh People's Hospital,Hangzhou310013,China)

机构地区：[1]杭州市第七人民医院精神科,310013 [2]浙江大学心理健康教育与咨询中心

出　　处：《浙江医学》2018年第21期2311-2315,共5页Zhejiang Medical Journal

基　　金：杭州市社会发展自主申报项目(20160533B31)

摘　　要：目的探讨催产素对早发性精神分裂症患者心理理论及共情能力的影响。方法将60例早发性精神分裂症患者随机分成催产素组(左右鼻孔交替喷催产素共6次、催产素0.6ml;每隔2d给药1次,共给药5次)和安慰剂组(鼻孔喷入0.9%氯化钠溶液,操作方法与催产素组相同),每组30例;其中安慰剂组脱落4例,最终纳入26例。比较两组患者YONI认知与情感心理理论任务、心理推理能力故事图片任务、中文版人际反应指针量表、疼痛共情范式的评估结果。结果心理理论能力方面,催产素组患者干预后认知心理理论、情感心理理论的一级推理得分、等级错误信念得分均明显高于干预前(均P<0.05),亦明显高于安慰剂组(均P<0.05);而干预后控制条件的一级推理得分,认知心理理论、情感心理理论、控制条件的二级推理得分,等级信念、现实相关问题得分比较,两组患者比较差异均无统计学意义(均P>0.05)。在共情能力方面,催产素组患者干预后共情性关心(EC)得分、疼痛图片判断正确率均明显高于干预前(均P<0.05),亦明显高于安慰剂组(均P<0.05);而干预后观点采择(PT)、想象力(FS)、个人痛苦(PD)得分及中性图片判断正确率,两组患者比较差异均无统计学意义(均P>0.05)。结论催产素可能对早发精神分裂症患者的低级心理理论能力及共情能力具有改善作用。Objective To explore the effect of tntranasal oxytocin administration on theory of mind and empathy in patients with early onset schizophrenia(EOS).Methods Sixty patients with EOS were randomly assigned to oxytocin group(n=30)and control group(n=30).Patients in oxytocin group were given nasal spray of 24 IU oxytocin every two days for 5 times,those in control group were given 0.9%saline for nasal spray.Four cases in control group were dropped out and finally 26 cases completed the study.All patients were assessed with YONI task,theory of mind picture-sequencing task(ToM-PST),Chinese version of interpersonal reactivity index(IRI-C),empathy for pain paradigm(EPP).Results The first-order cognitive/affective condition of the YONI task,understanding order error belief in the ToM-PST(P<0.05)in oxytocin group were improved significantly after treatment,and also better than those in control group(P<0.05).There were no significant differences in first-order psysical condition and the second-order cognitive/affective/psysical condition of the YONI task,understanding order belief and related to the present condition in the ToM-PST between two groups(P>0.05).Oxytocin group performed better in the empathy concern in IRI-C and the accuracy of painful pictures in EPP after treatment(P<0.05),and also better than placebo group(P<0.05),while the two group had no significant differences in the PT,FS and PD in IRI-C and the accuracy of neutral pictures in EPP(P>0.05).Conclusion Intranasal oxytocin administration may improve on low order ToM and empathy in patients with early onset schizophrenia.

关 键 词：早发性精神分裂症 心理理论能力 共情能力 催产素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]