Scope of translational medicine in developing boroncontaining compounds for therapeutics  

作　　者：Ana Karen García-ávila Eunice Dalet Farfán-García Juan Alberto Guevara-Salazar José Guadalupe Trujillo-Ferrara Marvin Antonio Soriano-Ursúa 

机构地区：[1]Department of Biochemistry and Section of Post Graduate Studies and Research,Escuela Superior de Medicina,Instituto Politécnico Nacional [2]Department of Physiology and Section of Post Graduate Studies and Research,Escuela Superior de Medicina,Instituto Politécnico Nacional

出　　处：《World Journal of Translational Medicine》2017年第1期1-9,共9页世界转化医学杂志

基　　金：Supported by Secretaria de Investigación y Posgrado del Instituto Politécnico Nacional,No.SIP-1754 20170411;the National Council of Science and Technology,No.CONACYT,CB-235785

摘　　要：The ubiquitousness of naturally occurring boron-containing compounds(BCCs) has led to their constant contact with humankind.Recently,many synthetic BCCs have been elaborated for a broad spectrum of purposes,especially boric,boronic and borinic acids.Although BCCs were once employed primarily as antiseptics and later as antibiotics,they have become an increasingly relevant therapeutic tool.Nevertheless,this potential of BCCs has been drastically limited due to some unfortunate intra-hospital accidents in the 1940 s and 1950 s.The increasing use of BCCs as insecticides,antimicrobials,and other agents is providing new insights into their role in the physiology of several living species and in the pathophysiology of humans.It is becoming clear that BCCs act through a wide range of mechanisms,as do their corresponding boron-free counterparts.When comparing BCCs and similar boron-free compounds,in many cases the former show advantages in the medical field.The current minireview focuses on how BCCs have been developed by means of translational medicine,a process connecting biomedical research with clinical applications.This process of discovery is currently in an exponential stage.The ubiquitousness of naturally occurring boron-containing compounds(BCCs) has led to their constant contact with humankind.Recently,many synthetic BCCs have been elaborated for a broad spectrum of purposes,especially boric,boronic and borinic acids.Although BCCs were once employed primarily as antiseptics and later as antibiotics,they have become an increasingly relevant therapeutic tool.Nevertheless,this potential of BCCs has been drastically limited due to some unfortunate intra-hospital accidents in the 1940 s and 1950 s.The increasing use of BCCs as insecticides,antimicrobials,and other agents is providing new insights into their role in the physiology of several living species and in the pathophysiology of humans.It is becoming clear that BCCs act through a wide range of mechanisms,as do their corresponding boron-free counterparts.When comparing BCCs and similar boron-free compounds,in many cases the former show advantages in the medical field.The current minireview focuses on how BCCs have been developed by means of translational medicine,a process connecting biomedical research with clinical applications.This process of discovery is currently in an exponential stage.

关 键 词：Boron Boron-containing COMPOUNDS Drug development Toxicity MEDICINAL chemistry PHARMACOLOGY 

分 类 号：R[医药卫生]