MOG抗体病一例  

One case of MOG antibody disease

作　　者：丁岩[1] 万桂玲 苏圣尧 刘小广 刘峥[1] 董会卿[1] Ding Yan;Wan Guiling;Su Shengyao;Liu Xiaoguang;Liu Zheng;Dong Huiqing(Department of Neurology,the Xuanwu Hospital of Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院神经内科,北京100053

出　　处：《脑与神经疾病杂志》2018年第11期699-703,共5页Journal of Brain and Nervous Diseases

摘　　要：目的了解一种新的特发性中枢神经系统脱髓鞘病-MOG抗体病的临床特点及诊治思路。方法报道本院收治的1例13岁发病到21岁,病程8年,7次临床发作MOG抗体病患者的临床表现、辅助检查以及治疗预后的特点。结果 MOG抗体病儿童与成人发病的临床表现形式不同,13岁至17岁以类似ADEM的表现形式为主,而17岁至21岁则以复发的视神经炎的表现形式为主。MOG抗体病治疗与其他的特发性中枢神经系统脱髓鞘病的治疗一致,易复发但是激素治疗效果好,预后好。结论儿童期表现为ADEM和ADEM样症状以及成年人表现为视神经炎、AQP4-Ab阴性的NMOSD以及不典型的MS的患者,需要检测MOG抗体有助于诊治。Objective To investigate the clinical features,diagnosis and treatment of a new idiopathic central nervous system demyelinating disease MOG antibody disease.Method Report the clinical manifestations,auxiliary examinations,treatment and prognosis of a 21-year old patient diagnosed with MOG antibody disease in our hospital,who has had 7 attacks since he had onset at age 13.Results The clinical manifestations of children and adults are different in MOG antibody disease.The patient was mainly in the form of ADEM-like encephalopathy during the age of 13-17,while primarily presented recurrent optic neuritis at a later age between 17-21.The treatment of MOG antibody disease is consistent with the other idiopathic central nervous system demyelinating diseases.Although MOG antibody disease is easy to relapse,it has favourable prognosis due to its sensitivity to glucocorticoid therapy.Conclusion The patients manifesting as ADEM and ADEM-like in children,as well as optic neuritis,AQP4-antibody negative NMOSD and atypital MS in adults,should be detected the MOG antibody for better diagnosis and treatment.

关 键 词：髓鞘少突胶质细胞糖蛋白 特发性炎性脱髓鞘病 视神经脊髓炎 MOG抗体病 

分 类 号：R745.4[医药卫生—神经病学与精神病学]