Low expression of angiotensinogen and dipeptidyl peptidase 1 in saliva of patients with proliferative verrucous leukoplakia  

作　　者：Isadora Luana Flores Alan Roger Santos-Silva Ricardo Della Coletta Adriana Franco Paes Leme Marcio Ajudarte Lopes 

机构地区：[1]Oral Diagnosis Department,Piracicaba Dental School,University of Campinas(UNICAMP) [2]Mass Spectrometry Laboratory,Brazilian Biosciences National Laboratory (LNBio)

出　　处：《World Journal of Clinical Cases》2016年第11期356-363,共8页世界临床病例杂志

摘　　要：AIM To elucidate the profile of the salivary proteome.METHODS Unstimulated whole mouth saliva was collected from 30 volunteers [15 proliferative verrucous leukoplakia(PVL) patients and 15 controls] and proteins were submitted for mass spectrometry-based proteomics using the discovery approach,followed by analyses of variance and logistic regression tests.RESULTS A total of two hundred and eighty-three proteins were confidently identified in saliva.By combining two low abundance proteins from the PVL group,angiotensinogen(AGT) and dipeptidyl peptidase 1(DPP1),a model for group differentiation was built with a concordance index of 94.2%,identifying both proteins as potential etiologic biomarkers for PVL.CONCLUSION This study suggests that both AGT and DPP1 may be involved in developmental mechanisms of PVL.AIM To elucidate the profile of the salivary proteome.METHODS Unstimulated whole mouth saliva was collected from 30 volunteers [15 proliferative verrucous leukoplakia(PVL) patients and 15 controls] and proteins were submitted for mass spectrometry-based proteomics using the discovery approach,followed by analyses of variance and logistic regression tests.RESULTS A total of two hundred and eighty-three proteins were confidently identified in saliva.By combining two low abundance proteins from the PVL group,angiotensinogen(AGT) and dipeptidyl peptidase 1(DPP1),a model for group differentiation was built with a concordance index of 94.2%,identifying both proteins as potential etiologic biomarkers for PVL.CONCLUSION This study suggests that both AGT and DPP1 may be involved in developmental mechanisms of PVL.

关 键 词：SALIVA ANGIOTENSINOGEN Dipeptidyl peptidase 1 Biomarkers Proliferative verrucous leukoplakia LC-MS/MS 

分 类 号：R781.5[医药卫生—口腔医学]