Aetiology of idiopathic granulomatous mastitis  

作　　者：Fatih Altintoprak Taner Kivilcim Orhan Veli Ozkan 

机构地区：[1]Department of General Surgery, Sakarya University Faculty of Medicine, 54100 Sakarya, Turkey [2]Department of General Surgery, Sakarya University Research and Educational Hospital, 54100 Sakarya, Turkey

出　　处：《World Journal of Clinical Cases》2014年第12期852-858,共7页世界临床病例杂志

摘　　要：Idiopathic granulomatous mastitis is a rare chronic inflammatory lesion of the breast that can clinically and radiographically mimic breast carcinoma. The most common clinical presentation is an unilateral, discrete breast mass, nipple retraction and even a sinus formation often associated with an inflammation of the overlying skin. The etiology of idiopathic granulomatous mastitis is still obscure. Its treatment remains controversial. The cause may be the autoimmune process, infection, a chemical reaction associated with oral contraceptive pills, or even lactation. Various factors, including hormonal imbalance, autoimmunity, unknown microbiological agents, smoking and α 1-antitrypsin deficiency have been suggested to play a role in disease aetiology. In this review, causing factors in the aetiology of idiopathic granulomatous mastitis are reviewed in detail.Idiopathic granulomatous mastitis is a rare chronic inflammatory lesion of the breast that can clinically and radiographically mimic breast carcinoma. The most common clinical presentation is an unilateral, discrete breast mass, nipple retraction and even a sinus formation often associated with an inflammation of the overlying skin. The etiology of idiopathic granulomatous mastitis is still obscure. Its treatment remains controversial. The cause may be the autoimmune process, infection, a chemical reaction associated with oral contraceptive pills, or even lactation. Various factors, including hormonal imbalance, autoimmunity, unknown microbiological agents, smoking and α 1-antitrypsin deficiency have been suggested to play a role in disease aetiology. In this review, causing factors in the aetiology of idiopathic granulomatous mastitis are reviewed in detail.

关 键 词：MASTITIS GRANULOMATOUS MASTITIS IDIOPATHIC GRANULOMATOUS MASTITIS GRANULOMATOUS LOBULAR MASTITIS INFLAMMATION 

分 类 号：R655.8[医药卫生—外科学]