Low ADAMTS-13 in plavix induced thrombotic thrombocytopenic purpura  

作　　者：Long Bao Cao Christopher Jones Assad Movahed 

机构地区：[1]Department of Cardiovascular Sciences, Brody School of Medicine,East Carolina University, Greenville, NC 27834, United States

出　　处：《World Journal of Clinical Cases》2013年第1期31-33,共3页世界临床病例杂志

基　　金：Supported by The "East Carolina Heart Institute"

摘　　要：Thrombotic thrombocytopenia purpura(TTP) was fi rst described in 1924 as a "pathologic alteration of the microvasculature, with detachment or swelling of the endothelium, amorphous material in the sub-endothelial space, and luminal platelet aggregation leading to compromise of the microcirculation". Ticlopidine induced TTP has been highly associated with autoimmune induced reduction in ADAMTS-13 activity. These findings, to a lesser extent, have also been found in clopidogrel induced TTP. We report a case of clopidogrel associated TTP in a patient that presented with acute stroke, renal failure, and non-ST elevation myocardial infarction.Thrombotic thrombocytopenia purpura(TTP) was fi rst described in 1924 as a "pathologic alteration of the microvasculature, with detachment or swelling of the endothelium, amorphous material in the sub-endothelial space, and luminal platelet aggregation leading to compromise of the microcirculation". Ticlopidine induced TTP has been highly associated with autoimmune induced reduction in ADAMTS-13 activity. These findings, to a lesser extent, have also been found in clopidogrel induced TTP. We report a case of clopidogrel associated TTP in a patient that presented with acute stroke, renal failure, and non-ST elevation myocardial infarction.

关 键 词：PLAVIX THROMBOTIC THROMBOCYTOPENIC PURPURA ANTIPLATELET therapy 

分 类 号：R554.6[医药卫生—血液循环系统疾病]