血小板/淋巴细胞比值对肝细胞癌的预后价值评价  

Prognostic value of platelet-to-lymphocyte ratio for hepatocellular carcinoma

作　　者：胡琼英[1] 罗建蓉[2] 艾承锦[1] 陈高莉 张爽[1] 张朝明[1] HU Qiong-ying;LUO Jian-rong;AI Cheng-jin;CHEN Gao-li;ZHANG Shuang;ZHANG Chao-ming(Department of Laboratory Medicine,Teaching Hospital,Chengdu University of TCM,Chengdu 610072,China;Department of Laboratory Medicine,Qionglai Medical Center Hospital,Chengdu 611530,China)

机构地区：[1]成都中医药大学附属医院检验科,四川成都610072 [2]四川省邛崃市医疗中心医院检验科,四川邛崃611530

出　　处：《实用医院临床杂志》2018年第6期78-80,共3页Practical Journal of Clinical Medicine

基　　金：国家自然科学基金资助项目(编号:81601835);四川省科技厅面上项目(编号:18YYJC0689);中华医学会教育项目(编号:2016B-FF095);四川省医学会科研基金资助项目(编号:S15023);成都中医药大学青年基金资助项目(编号:ZRQN1730;030038065)

摘　　要：目的分析肝细胞癌(Hepatocellular carcinoma,HCC)患者血小板/淋巴细胞比值(Platelet-to-lymphocyte ratio,PLR),评价其对HCC的预后价值。方法我院首次确诊的100例HCC患者,经治疗随访,分为生存组和死亡组,抽取EDTA抗凝静脉血,检测淋巴细胞计数绝对值和血小板计数值,计算PLR,并绘制受试者工作曲线(ROC曲线)找到cut-off值,评价其预测价值。结果 100例HCC患者中22例(22%)在平均随访期11个月内死亡,生存者与死亡者的PLR差异有统计学意义(P=0. 001),此时的cut-off值为208,预测的敏感度和特异性分别为64. 2%和75. 2%,ROC曲线下面积(AUC)为0. 75。结论PLR高于208时,提示HCC患者预后不良,PLR是一种廉价,易得的血常规结果,可作为HCC潜在的预后指标。To investigate the prognostic value of platelet-to-lymphocyte ratio(PLR)in patients with hepatocellular carcinoma(HCC).We retrospectively analyzed 100 patients with first diagnosis of HCC.These patients were followed-up after treatment and divided into survival and death groups.EDTA-anticoagulated venous blood was analyzed for complete blood counts.PLR was calculated and receiver operator characteristic curve(ROC)analysis was performed to assess the prognostic value of PLR in HCC after a cut-off value was determined.Among the 100 patients,22(22%)patients died within an average follow-up period(11 months).There was a statistical significance in PLR between the two groups(P=0.001).The optimal cut-off value was determined to be 208.The sensitivity was 64.2%,the specificity was 75.2%,and the area under the ROC curve(AUC)was 0.75.Our results indicate that PLR>208 predicts a poor prognosis in HCC patients.PLR is a low-cost and convenient tool that may be served as a useful prognostic marker for HCC.

关 键 词：血小板/淋巴细胞比值 肝细胞癌 预后价值 

分 类 号：R735.7[医药卫生—肿瘤]