Fever tree revisited:From malaria to autoinflammatory diseases  

作　　者：Serena Pastore Josef Vuch Anna Monica Bianco Andrea Taddio Alberto Tommasini 

机构地区：[1]Department of Pediatrics,Institute for Maternal and Child Health,IRCCS Burlo Garofolo [2]Department of Medical Surgical and Health Sciences,University of Trieste [3]Department of Laboratory,Institute for Maternal and Child Health,IRCCS Burlo Garofolo

出　　处：《World Journal of Clinical Pediatrics》2015年第4期106-112,共7页世界临床儿科杂志

摘　　要：Over the centuries the idea of recurrent fevers has mainly been associated with malaria, but many other fevers, such as typhoid and diphtheria were cause for concern. It is only in recent times, with the more severe forms of fever from infectious origin becoming less frequent or a cause for worry that we started noticing recurrent fevers without any clear infectious cause, being described as having a pathogenesis of autoinflammatory nature. The use of molecular examinations in many cases can allow a diagnosis where the cause is monogenic. In other cases, however the pathogenesis is likely to be multifactorial and the diagnostic-therapeutic approach is strictly clinical. The old fever tree paradigm developed to describe fevers caused by malaria has been revisited here to describe today's periodic fevers from the periodic fever adenitis pharyngitis aphthae syndrome to the more rare autoinflammatory diseases. This model may allow us to place cases that are yet to be identified which are likely to be of multifactorial origin.Over the centuries the idea of recurrent fevers has mainly been associated with malaria, but many other fevers, such as typhoid and diphtheria were cause for concern. It is only in recent times, with the more severe forms of fever from infectious origin becoming less frequent or a cause for worry that we started noticing recurrent fevers without any clear infectious cause, being described as having a pathogenesis of autoinflammatory nature. The use of molecular examinations in many cases can allow a diagnosis where the cause is monogenic. In other cases, however the pathogenesis is likely to be multifactorial and the diagnostic-therapeutic approach is strictly clinical. The old fever tree paradigm developed to describe fevers caused by malaria has been revisited here to describe today's periodic fevers from the periodic fever adenitis pharyngitis aphthae syndrome to the more rare autoinflammatory diseases. This model may allow us to place cases that are yet to be identified which are likely to be of multifactorial origin.

关 键 词：Recurrent fevers MALARIA AUTOINFLAMMATORY diseases Periodic FEVER ADENITIS pharyngytis aphthe syndrome History of medicine INTERLEUKIN-1 Genetics The FEVER TREE 

分 类 号：R725[医药卫生—儿科]