CD29的表达与人类唾液腺良恶性肿瘤发病关系的研究  

Relationship between Expression of CD29 and Pathogenesis of Human Salivary Gland Benign and Malignant Tumors

作　　者：刘鑫灿[1] 张德保[1] 刘仔龙 LIU Xin-can;ZHANG De-bao;LIU Zai-long(Department of Stomatology,The First Affiliated Hospital of University of South China,Hengyang 421001,China)

机构地区：[1]南华大学附属第一医院口腔科,湖南衡阳421001

出　　处：《口腔医学研究》2018年第11期1204-1207,共4页Journal of Oral Science Research

摘　　要：目的:分析与明确各种细胞表面标记物的表达和分布,特别是CD29在成人唾液腺中的表达和分布。方法:采集成对的成人腮腺、舌下腺和颌下腺组织。并使用免疫组化检测收集的腺体中各种家族特异性细胞表面标记的表型表达(包括CD29)。结果:发现CD29在唾液腺腺泡和导管上皮,间充质基质和肌上皮细胞上均有表达;CD29+细胞在成人唾液腺上皮中与CD324、CD326、NKCC1和CD44共表达;间充质细胞主要表达CD73、CD90、波形蛋白和CD34而α-SMA主要是肌上皮细胞特异性祖细胞标记物。结论:CD29广泛表达于人唾液腺中,可作为唾液腺疾病和恶性肿瘤新型细胞治疗和诊断的潜在生物标志物。Objective:To analyze and clarify the expression and distribution of various cell surface markers,especially the expression and distribution of CD29 in adult salivary glands.Methods:Paired adult parotid,sublingual and submandibular glands were collected.The phenotypic expression(including CD29)of various family-specific cell surface markers in the collected glands was examined using immunohistochemistry.Results:CD29 was expressed in the salivary gland acinar and duct epithelium,mesenchymal stroma,and myoepithelial cells.CD29+cells were co-expressed in adult salivary gland epithelium with CD324,CD326,NKCC1,and CD44.Mesenchymal cells mainly expressed CD73,CD90,vimentin,and CD34.Andα-SMA was the predominantly myoepithelial cell-specific progenitor markers.Conclusion:CD29 is widely expressed in human salivary glands and can be used as a potential biomarker for the treatment and diagnosis of salivary gland diseases and malignant tumors.

关 键 词：成人 CD 29 祖细胞 唾液腺 干细胞 

分 类 号：R739.8[医药卫生—肿瘤]