蛹虫草对小鼠的毒理学实验研究  

Toxicity Studies of Cordyceps militaris in Mice

作　　者：宋述锐 刘新平 魏姗姗 刘小然 姚丽华 SONG Shu-rui;LIU Xin-ping;WEI Shan-shan;LIU Xiao-ran;YAO Li-hua(School of Life Sciences,Jiangxi Science&Technology Normal University,Nanchang 330013,China;Jiangxi Guben Biotechnology Co.,Ltd.,Nanchang 330096,China)

机构地区：[1]江西科技师范大学生命科学学院,南昌330013 [2]江西固本生物科技有限公司,南昌330096

出　　处：《天然产物研究与开发》2018年第11期1878-1883,共6页Natural Product Research and Development

基　　金：国家自然科学基金(31660275;81360205);江西省杰出青年人才项目(20171BCB23077)

摘　　要：为对蛹虫草进行急性毒理学和亚急性毒理学的实验研究,急性毒理实验中,本研究以45 mg/100 g的浓度经口灌胃,每天3次;亚急性毒理实验中,分别以低浓度剂量(1 mg/100 g、5 mg/100 g)、中等浓度剂量(25 mg/100 g)和高浓度剂量(125 mg/100 g)经口灌胃小鼠,每天1次。结果表明,急性毒理实验中,小鼠出现了明显的毒性副作用;亚急性毒理实验进一步发现,低、中剂量的蛹虫草每天1次经口灌胃对小鼠不产生明显的毒性副作用,但高剂量的蛹虫草对小鼠有较明显的毒性副作用。结果表明,小鼠蛹虫草经口灌胃浓度在1~25 mg/100 g/d剂量下对机体生理功能不具有明显的毒副作用。The objective of the study was to evaluate the safety of the Cordyceps militaris so as to demonstrate the applicability for daily use.In acute oral toxicity studies,the mice were fed with 0.4 mL(45 mg/100 g)Cordyceps militaris three times per day for 14 days.In the subacute oral toxicity test,the mice were fed with 0.4 mL Cordyceps militaris once per day in different concentrations(low concentration:1 mg/100 g,5 mg/100 g;intermediate concentration:25 mg/100 g and higher concentration:125 mg/100 g)for 28 days.In acute oral toxicity studies,deaths were found in the treatment group.In the case of the subacute oral toxicity test,no death was found in the group of low and intermediate concentrations.However,death and other treatment related complications were found in the higher concentration group in the 28-day and severe damage of the vital organs,including kidney and liver.These results demonstrated that Cordyceps militaris produced no death or treatment related toxicity in mice in the concentrations of 1-25 mg/100 g.Thus,Cordyceps militaris could be regarded as a safety nourishment in daily use.

关 键 词：蛹虫草 急性毒理 亚急性毒理 安全性 

分 类 号：R992[医药卫生—毒理学]