阿加曲班联合丁苯酞治疗急性脑梗死的临床疗效探讨  

Clinical efficacy of argatroban combined with butylphthalide in the treatment of acute cerebral infarction

作　　者：张雨时[1] ZHANG Yu-shi(Shenyang 242 Hospital,Shenyang 110034,China)

机构地区：[1]沈阳二四二医院,110034

出　　处：《中国现代药物应用》2018年第22期85-87,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨阿加曲班联合丁苯酞治疗急性脑梗死(ACI)患者的临床疗效。方法 148例急性脑梗死患者,随机分为对照组和观察组,各74例。对照组给予丁苯酞治疗,观察组给予阿加曲班联合丁苯酞治疗,比较两组患者的治疗效果、治疗前后神经缺损程度改善情况及血清炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]情况。结果治疗前,两组美国国立卫生研究院卒中量表(NIHSS)评分比较差异无统计学意义(P>0.05);治疗后,观察组NIHSS评分为(7.64±3.72)分,低于对照组的(10.45±2.94)分,差异有统计学意义(P<0.05)。观察组治疗总有效率为94.59%,高于对照组的75.68%,差异有统计学意义(P<0.05)。治疗前,两组TNF-α、IL-6及hs-CRP水平比较差异无统计学意义(P>0.05);治疗后,观察组TNF-α、IL-6及hs-CRP水平均低于对照组,差异有统计学意义(P<0.05)。结论阿加曲班联合丁苯酞治疗急性脑梗死患者,能够有效改善患者神经缺损程度,降低血清炎症因子水平,具有临床推广价值。Objective To discuss the clinical efficacy of argatroban combined with butylphthalide in the treatment of acute cerebral infarction(ACI).Methods A total of 148 acute cerebral infarction patients were randomly divided into control group and observation group,with 74 cases in each group.The control group was treated with butylphthalide,and the observation group was treated with argatroban combined with butylphthalide.Comparison were made on treatment effect,improvement of neurological deficit and serum inflammatory factors[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]before and after treatment between the two groups.Results There was no statistically significant difference in National Institutes of Health Stroke Scale(NIHSS)score(P>0.05).After treatment,the observation group had lower NIHSS score as(7.64±3.72)points than(10.45±2.94)points in the control group,and the difference was statistically significant(P<0.05).The observation group had higher total treatment effective rate as 94.59%than 75.68%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in TNF-α,IL-6 and hs-CRP level(P>0.05).After treatment,the observation group had lower TNF-α,IL-6 and hs-CRP level than the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of argatroban and butylphthalide can effectively improve the degree of neurological deficit and lower serum inflammatory factor level of patients with acute cerebral infarction,and this method contains clinical promotion value.

关 键 词：急性脑梗死 阿加曲班 丁苯酞 神经缺损程度 血清炎症因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]