神经肽Y受体系统参与痛觉调制的研究进展  

Advance in Role of Neuropeptide Y Receptors System in Pain Modulation(review)

作　　者：赵舒煊 张东亮 沈伟 冯晓飞 刘正 袁文华 周海宇[1] ZHAO Shu-xuan;ZHANG Dong-liang;SHEN Wei;FENG Xiao-fei;LIU Zheng;YUAN Wen-hua;ZHOU Hai-yu(Department of Orthopedics,Second Hospital of Lanzhou University,Lanzhou,Gansu 730030,China;Key Laboratory of Bone and Joint Diseases of Gansu Province,Lanzhou,Gansu 730030,China)

机构地区：[1]兰州大学第二医院骨科,甘肃兰州市730030 [2]甘肃省骨关节疾病研究重点实验室,甘肃兰州市730030

出　　处：《中国康复理论与实践》2018年第11期1284-1287,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：甘肃省自然科学基金项目(No.17JR5RA189)~~

摘　　要：神经肽Y受体系统是由神经肽Y (NPY)及其哺乳动物体内特异性受体组成的受体-配体系统,广泛参与哺乳动物内痛觉调制,以Y1受体(Y1R)和Y2受体(Y2R)两类亚型为代表。此类受体属G蛋白偶联受体,参与神经元膜信号转导,在中枢神经系统痛觉相关区域广泛分布,不同受体在颅内和脊髓水平分布具有特异性。NPY通过与Y1R和Y2R结合,维持痛觉传递过程的稳态。其中,脊髓水平结合Y1R可发挥镇痛效用,结合Y2R通常可发挥促痛作用。颅内调制功能则与特定区域核团功能有关。The neuropeptide Y receptors system is a receptor-ligand system composed of neuropeptide Y and its receptors,which is represented by two subtypes,including Y1 receptor(Y1R)and Y2 receptor(Y2R).The system is widely involved in pain modulation in mammals.These receptors are G protein-coupled receptors,participating in neuronal membrane signaling.Neuropeptide Y receptors distribute in the pain-related regions of the central nervous system,play a variety of roles in maintains neuronal activity of pain transmission,relate to the specificity of distribution.At the spinal level,Y1R plays an analgesic role,whereas Y2R is usually related to pain-promoting.The system can also take part in cerebral pain modulation at different nuclei.

关 键 词：神经肽Y 受体 痛觉调制 综述 

分 类 号：R741.02[医药卫生—神经病学与精神病学]