Post splenectomy related pulmonary hypertension  

作　　者：Atul V Palkar Abhinav Agrawal Sameer Verma Asma Iftikhar Edmund J Miller Arunabh Talwar 

机构地区：[1]Department of Pulmonary,Critical Care and Sleep Medicine,North Shore-LIJ Health System [2]Department of Medicine,Monmouth Medical Center [3]Feinstein Institute of Medical Research,Center for Heart and Lung Research

出　　处：《World Journal of Respirology》2015年第2期69-77,共9页世界呼吸病学杂志

基　　金：Supported by NIH 1R01HL111469;ECRIP Fellowship

摘　　要：Splenectomy predisposes patients to a slew of infectious and non-infectious complications including pulmonary vascular disease. Patients are at increased risk for venous thromboembolic events due to various mechanisms that may lead to chronic thromboembolic pulmonary hypertension(CTEPH). The development of CTEPH and pulmonary vasculopathy after splenectomy involves complex pathophysiologic mechanisms, some of which remain unclear. This review attempts to congregate the current evidence behind our understanding about the etio-pathogenesis of pulmonary vascular disease related to splenectomy and highlight the controversies that surround its management.Splenectomy predisposes patients to a slew of infectious and non-infectious complications including pulmonary vascular disease. Patients are at increased risk for venous thromboembolic events due to various mechanisms that may lead to chronic thromboembolic pulmonary hypertension(CTEPH). The development of CTEPH and pulmonary vasculopathy after splenectomy involves complex pathophysiologic mechanisms, some of which remain unclear. This review attempts to congregate the current evidence behind our understanding about the etio-pathogenesis of pulmonary vascular disease related to splenectomy and highlight the controversies that surround its management.

关 键 词：PULMONARY HYPERTENSION THALASSEMIA SPLENECTOMY THROMBOCYTOSIS Chronic THROMBOEMBOLIC PULMONARY HYPERTENSION 

分 类 号：R[医药卫生]