基于扫频源相干光断层成像原理与部分相干光干涉原理的生物测量仪在眼轴测量中的比较  

A Comparison of Axial Length Measurements with Swept-Source Optical Coherence Tomography Biometry and Partial Coherence Interferometry AL-Scan

作　　者：李逸丰 杨文利 李栋军 王子杨 陈伟 赵琦 崔蕊 沈琳 鲜军舫 Yifeng Li;Wenli Yang;Dongjun Li;Ziyang Wang;Wei Chen;Qi Zhao;Rui Cui;Lin Shen;Junfang Xian(Department of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,眼科学与视觉科学北京市重点实验室,100730

出　　处：《中华眼视光学与视觉科学杂志》2018年第11期648-652,共5页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：北京市医院管理局临床医学发展专项经费资助(ZYLX201704);北京市卫生系统高层次人才培养计划学科带头人项目(2014-2-005)。

摘　　要：目的:比较基于扫频源相干光断层成像原理的OA2000和基于部分相干光干涉原理的AL-Scan在白内障患者眼轴长度测量中的检出率、差异性及一致性。方法:系列病例研究。纳入2017年11月29日至12月15日在首都医科大学附属北京同仁医院眼科门诊就诊,并拟行白内障手术的白内障患者210例(378眼)为研究对象,使用2种生物测量仪OA2000和AL-Scan检测眼轴长度。分别计算2种仪器的眼轴检出率。采用配对t检验比较2种仪器眼轴测量结果间的差异性。采用Pearson相关分析评价2种仪器测量间的相关性。采用组内相关系数(ICC)及Bland-Altman法评价仪器的一致性。并将研究眼分为眼轴<22mm组、眼轴22~26mm组、眼轴>26mm组,使用Bland-Altman法分别评价每组一致性。结果:OA2000和AL-Scan的眼轴检出率分别为98.4%和90.2%,差异有统计学意义(χ2=56.19,P<0.001)。OA2000和AL-Scan检测眼轴长度分别为(24.532±2.678)mm和(24.526±2.679)mm,差异无统计学意义(t=1.847,P=0.066)。2种仪器测量的眼轴长度结果具有密切相关性(r=1.000,P<0.001),ICC为1.000,Bland-Altamn分析95%一致性界限范围为0.23mm(-0.12~0.11mm)。95%一致性界限范围在眼轴<22mm组、眼轴22~26mm组、眼轴>26mm组分别为0.20mm(-0.10~0.10mm)、0.20mm(-0.09~0.11mm)、0.33mm(-0.16~0.17mm),3组的线外点分别为7.7%、4.5%、8.4%。结论:在白内障患者的眼轴测量中,OA2000比AL-Scan具有更高的眼轴检出率。2种仪器眼轴检测结果的相关性及一致性良好,尤其眼轴范围在22~26mm的患者中一致性表现最佳。2者数据可以相互替代使用。Objective:To compare a swept-source coherence tomography(SS-OCT)biometer(OA2000)with partial coherence interferometry(PCI)AL-Scan in terms of the axial length measurement success rate in eyes with cataract.Methods:A total of 378 eyes of 210 patients from the Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University were included in this case series study from November 29th to December 15th 2017.The axial lengths of these eyes were measured with the two biometers and the axial length measurement success rates with the instruments were assessed.A paired t test was used to compare the difference in axial length measurements between the two instruments and a Pearson correlation analysis was used to assess the correlation between the two biometers.The intra-group correlation coefficient(ICC)and the Bland-Altman method were used to assess the agreement in axial length measurements between the two biometers.The sampled eyes were divided into three groups:axial lengths less than 22 mm,22-26 mm and over 26 mm.The Bland-Altman method was used to assess the agreement in axial length measurements between these three groups.Results:The success rates of OA2000 and AL-Scan were 98.4%and 90.2%,respectively,with a statistically significant difference between the two(χ2=56.19,P<0.001).The axial lengths measured with the two biometers were 24.532±2.678 mm and 24.526±2.679 mm,with a difference of 0.006±0.058 mm.The difference was not statistically significant(t=1.847,P=0.066).The axial length measurements were closely correlated(r=1.000,P<0.001),and the ICC was 1.000.The 95%agreement range for Bland-Altman analysis was 0.23 mm(-0.12-0.11 mm).The 95%agreement range for the three groups mentioned above was 0.20 mm(-0.10-0.10 mm),0.20 mm(-0.09-0.11 mm)and 0.33 mm(-0.16-0.17 mm),respectively.Conclusions:The SS-OCT based OA2000 out performs the PCI based AL-Scan in terms of axial length measurements in eyes with cataracts.The correlation and agreement in axial length measurements with the two biometers were exce

关 键 词：OA2000 AL-Scan 眼轴 白内障 生物测量 

分 类 号：R770.4[医药卫生—眼科]