STAT3和STAT4基因单核苷酸多态性与肝细胞癌的相关性  

Association of single-nucleotide polymorphisms of STAT3 and STAT4 with hepatocellular carcinoma

作　　者：范敬静[1] 常彩芳[1] 王浩[1] FAN Jingjing;CHANG Caifang;WANG Hao(Department of Infectious Diseases,First Affiliated Hospital,Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院感染科,河北张家口075000

出　　处：《实用医学杂志》2018年第21期3593-3597,3602,共6页The Journal of Practical Medicine

基　　金：张家口市科技攻关计划项目(编号:1421140D)

摘　　要：目的探讨信号传导和转录激活因子3(STAT3)基因rs2293152位点和信号传导和转录激活因子4(STAT4)基因rs7574865位点单核苷酸多态性(SNPs)与肝细胞癌(HCC)遗传易感性的关联及与环境因素的交互作用。方法采用病例对照研究方法,选取HCC患者256例作为观察组,同期健康体检者256例作为对照组,检测两组rs2293152、rs7574865位点SNPs。采用二分类Logistic回归模型分析rs2293152、rs7574865位点SNPs与HCC遗传易感性的关系,并探究rs2293152、rs7574865位点SNPs与环境因素的交互作用对HCC发病影响。结果两组间rs2293152、rs7574865位点基因型分布差异均无统计学意义(P> 0.05)。rs2293152位点G等位基因和rs7574865位点G等位基因均可显著增加HCC发病风险(P <0.05)。在饮酒与乙型肝炎病毒(HBV)感染人群中,rs2293152位点GG基因型相比GC+CC基因型,rs7574865位点GG基因型相比GT+TT基因型,HCC发病风险均显著升高(P <0.05)。rs2293152、rs7574865位点SNPs与饮酒、HBV感染均存在正交互作用。结论STAT3基因rs2293152位点和STAT4基因rs7574865位点SNPs与HCC遗传易感性明显相关,并与饮酒、HBV感染存在正交互作用,可增加HCC发病风险。Objective To investigate the associations of single-nucleotide polymorphisms(SNPs)of STAT3 and STAT4 with the hereditary susceptibility of hepatocellular carcinoma(HCC),and their interactions with environmental factors.Methods This study was a case-control study.256 hepatocellular carcinoma(HCC)patients were enrolled as the study group and 256 subjects undergoing physical examination at the same period were enrolled as the control group.The genotypes of locus rs229315 at STAT3 and rs7574865 at STAT4 were detected.Binary logistic regression analyses were used to explore the associations between SNPs of rs229315 and rs7574865 and the hereditary susceptibility of HCC,and their interactions with environmental factors.Results(1)No significant difference was observed between the two groups in the distribution of STAT3 rs229315 or STAT4 rs7574865 genotypes(P>0.05).(2)STAT3 rs229315 G alley and STAT4 rs7574865 G alley increased the risk of HCC(P<0.05).(3)Stratified analysis found that in alcohol or hepatitis B virus(HBV)infected people,rs2293152 GG genotype compared to GC+CC genotype,and rs7574865 GG genotype compared to GT+TT genotype,the risk of HCC elevated(P<0.05).(4)Gene-environment interaction assay indicated the SNP of STAT3 rs229315 was positively interacted with alcohol and HBV infection,and so was that of STAT4 rs7574865.Conclusions The SNPs of STAT3 rs229315 and STAT4 rs7574865 are closely related with the hereditary susceptibility of HCC,and positively interacts with alcohol,and HBV infection,which could increase the risk of HCC.

关 键 词：肝细胞癌 STAT3 STAT4 单核苷酸多态性 交互作用 

分 类 号：R735.7[医药卫生—肿瘤]