乌司他丁联合醒脑静对急性自发性脑出血老年患者的脑保护及预后  

Clinical observation on the cerebral protection and prognosis of patients with acute spontaneous intracerebral hemorrhage treated with ulinastatin and Xingnaojing

作　　者：邱志雄[1] 夏晓萍[1] 薛飞[1] 史轩丰[1] 何晓 刘冰[1] QIU Zhixiong;XIA Xiaoping;XUE Fei;SHI Xuanfeng;HE Xiao;LIU Bing(Emergency Department,Traditional Chinese Medicinal Hospital of Jiangyin City,Jiangyin 214400,China)

机构地区：[1]江阴市中医院急诊科,江苏江阴214400

出　　处：《皖南医学院学报》2018年第6期541-543,共3页Journal of Wannan Medical College

基　　金：江阴市科技三项(社会发展科技计划)(2911)

摘　　要：目的:探讨乌司他丁与醒脑静联合治疗对急性自发性脑出血老年患者脑保护及预后。方法:选取2015年1月～2017年6月我院收治的急性自发性脑出血老年患者98例,按数字随机表分为两组,各49例。对照组给予单纯乌司他丁治疗,观察组给予乌司他丁联合醒脑静治疗,比较两组治疗效果。结果:观察组治疗3、14 d后脑水肿面积均低于对照组,观察组治疗14 d后脑水肿吸收总有效率高于对照组,观察组治疗7、14 d后NIHSS评分均低于对照组,观察组治疗2个月后预后效果高于对照组,差异有统计学意义(P<0.05)。结论:乌司他丁联合醒脑静治疗急性自发性脑出血老年患者效果显著,可有效减少脑水肿面积,降低神经功能损伤,改善脑水肿吸收疗效及预后,值得推广。Objective:To observe the cerebral protective effect on and prognosis of patients with acute spontaneous intracerebral hemorrhage treated with ulinastatin plus Xingnaojing.Methods:Ninety-eight elderly patients with acute spontaneous cerebral hemorrhage admitted to and treated in our hospital were included from January 2015 to June 2017,and allocated to control group and observational group using random digital table(n=49 for each group).Patient in the control group received simple ulinastatin,while those in the observational group were treated with ulinastatin plus Xingnaojing.Then the two groups were compared regarding the therapeutic effects.Results:Patients in the observational group had lower intracerebral edema area in the 3rd and 14th day after therapy,better total edema absorption rate in the 14th day following medication,lower NIHSS scores in the 7th and 14th day,and better prognosis 2 months after treatment than those in the control group(all P<0.05).Conclusion:Combined ulinastatin with Xingnaojing can be better therapeutic effects for patients with acute spontaneous intracerebral hemorrhage.This treatment regimen may effectively reduce the brain edema area and neurological damage,yet improve brain edema absorption and prognosis,which is worthy of wider clinical recommendation.

关 键 词：乌司他丁 醒脑静 急性自发性脑出血 脑保护 预后 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R977.3[医药卫生—临床医学]