普利沙星的合成研究进展  

Progress in the Synthesis of Prulifloxacin

作　　者：夏奔航 陈志卫[1] XIA Ben-hang;CHEN Zhi-wei(Zhejiang University of Technology,Yangtze River Delta Green Pharmaceutical Collaborative Innovation Center,Hangzhou,Zhejiang 310014,China)

机构地区：[1]浙江工业大学长三角绿色制药协同创新中心,浙江杭州310014

出　　处：《浙江化工》2018年第11期6-11,共6页Zhejiang Chemical Industry

摘　　要：普利沙星属于第三代氟喹诺酮类抗菌药,是一种前药型的药物,具有抗菌谱广、抗菌效果好、不良反应少等优点,因此如何低廉高效地合成普利沙星是一项重要的课题。本文详细介绍了普利沙星的各条合成路线,并对各路线进行了优劣分析。Prulifloxacin is a third-generation fluoroquinolone antibacterial drug.It is a prodrug-type drug with the advantages such as broad antibacterial spectrum,low antibacterial effect and low adverse reactions.Therefore,it is an important topic to synthesize prulifloxacin inexpensively and efficiently.In this paper,the synthetic routes of prulifloxacin were introduced in details,and the advantages and disadvantages of each route were analyzed.

关 键 词：普利沙星 喹诺酮 合成 

分 类 号：TQ465[化学工程—制药化工]