HPV在宫颈癌前病变、宫颈癌中的表达水平及其临床意义  

Expression level of HPV in cervical precancerous lesions and cervical cancer and its clinical significance

作　　者：张佳佳[1] 石云[1] 李志丽[1] ZHANG Jiajia;SHI Yun;LI Zhili(The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第三附属医院,河南郑州450000

出　　处：《包头医学院学报》2018年第11期56-56,62,共2页Journal of Baotou Medical College

摘　　要：目的:探讨高危型人乳头瘤病毒(Human papillomavirus,HPV)在宫颈癌前病变、宫颈癌中的表达水平及其临床意义。方法:选择147例宫颈癌前病变、宫颈癌患者,根据术后病理检查分为宫颈癌前病变组79例与宫颈癌组68例,比较两组患者的HPV表达水平及其临床意义。结果:宫颈癌组患者HPV检测阳性率(75. 00%)高于宫颈癌前病变组患者(44. 30%)(X^2=12. 452,P=0. 001),宫颈癌组患者的HPV水平高于宫颈癌前病变组(t=25. 423,P=0. 000)。结论:临床检测HPV可提高宫颈癌癌前病变、宫颈癌筛查的检出率,利于宫颈癌的防治。Objective:To investigate the expression level of high-risk human papillomavirus(HPV)in cervical precancerous lesions and cervical cancer and its clinical significance.Methods:147 cases of patients with cervical precancerous lesions and cervical cancer were selected and,according to the postoperative pathological examination,divided into cervical precancerous lesions group(79 cases)and cervical cancer group(68 cases).The expression level and clinical significance of HPV in the two groups were compared.Results:The positive rate of HPV in cervical cancer group was 75.00%,which was higher than 44.30%in cervical precancerous lesion group,and the difference was statistically significant(χ^2=12.452,P=0.001).The level of HPV in cervical cancer group was significantly higher than that in cervical precancerous lesion group,and the difference was statistically significant(χ^2=25.423,P=0.000).Conclusion:Clinical detection of HPV can improve the detection rate of cervical precancerous lesions and cervical cancer screening,and is conducive to the prevention and treatment of cervical cancer.

关 键 词：宫颈癌前病变 宫颈癌 HPV 

分 类 号：R737.33[医药卫生—肿瘤]