丁苯酞注射液对不同OCSP分型的急性脑梗死患者的疗效观察  

Effect of butylphthalide injection on acute cerebral infarction based on OCSP typing

作　　者：张江 韩雪 宋方方 Zhang Jiang;Han Xue;Song Fangfang(Department of Neurology,Affiliated Hospital of North China University of Scienceand Technology,Tangshan 063000,Hebei Province,China)

机构地区：[1]华北理工大学附属医院神经内科二病区,唐山063000

出　　处：《中华老年心脑血管病杂志》2018年第11期1174-1178,共5页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：2015年河北省科技支撑计划项目(152777175);河北省医学适用技术跟踪项目(GL201649;G201754)

摘　　要：目的探讨丁苯酞注射液治疗不同OCSP分型的急性脑梗死患者的疗效。方法收集急性脑梗死患者299例,随机分为观察组149例(加用丁苯酞注射液治疗)和对照组150例。所有患者入院时均进行OCSP分型。记录2组患者入院时和治疗后2周及1个月时的美国国立卫生研究院卒中量表(NIHSS)评分和日常生活能力(BI)评分。比较2组患者的总体疗效以及2组相同亚型疗效。结果治疗后2周及1个月时,观察组NIHSS评分较对照组明显降低[(7.05±6.14)分vs(8.53±6.42)分、(4.56±5.55)分vs(6.09±5.68)分],BI评分较对照组显著升高[(75.91±18.22分vs(70.60±19.61)分、(84.36±17.31)分vs(78.60±18.66)分,P<0.05];观察组治疗总有效率较对照组高(P<0.01);且完全前循环梗死型(TACI)、部分前循环梗死型(PACI)和腔隙性脑梗死型(LACI)NIHSS评分较对照组明显降低,BI评分明显升高(P<0.05,P<0.01);2组TACI、PACI、POCI的NIHSS评分好转度分别大于LACI,TACI的NIHSS评分好转度、BI评分好转度大于PACI亚型(P<0.05/6)。结论丁苯酞注射液治疗OCSP分型的急性脑梗死患者均有较好疗效,可能更适用于TACI患者。Objective To study the effect of butylphthalide injection on acute cerebral infarction(ACI)based on OCSP typing.Methods Two hundred and ninety-nine ACI patients admitted to our hospital were randomly divided into observation group(n=149)treated with additional butylphthalide injection and control group(n=150).The patients were typed according to the OCSP on admission.Their NIHSS score and BI score were recorded on admission and after 2 weeks and1 month of treatment.The total curative effect for ACI and the curative effect for the same subtype ACI were comparatively analyzed.Results The NIHSS score was significantly lower while the BI score was significantly higher in observation group than in control group after 2 weeks and1 month of treatment(7.05±6.14 vs 8.53±6.42,4.56±5.55 vs 6.09±5.68,P<0.05;75.91±18.22 vs 70.60±19.61,84.36±17.31 vs78.60±18.66,P<0.05).The curative effect for ACI was better in observation group than in control group after 2 weeks and 1 month of treatment(P<0.01).The NIHSS score of TACI,PACI and LACI was significantly lower while the BI score was significantly higher in observation group than in control group after 2 weeks and 1 month of treatment(P<0.05,P<0.01).The NIHSS score of TACI,PACI,POCI was higher than that of LACI and TACI while the BI score was higher than that of PACI(P<0.05).Conclusion The curative effect of butylphthalide injection is rather good for TACI,PACI,POCI and LACI,especially for TACI in ACI patients.

关 键 词：脑梗死 线粒体 侧支循环 血栓溶解疗法 

分 类 号：R743.33[医药卫生—神经病学与精神病学]