肌细胞钙稳态的维持及模拟失重条件下钙稳态的改变  

The maintenance of calcium homeostasis in muscle cells and the changes of calcium homeostasis under simulated weightlessness

作　　者：余蕾 赵雪红 张静姝 樊小力[3] 李雪萍 朱娟霞 YU Lei;ZHAO Xue-hong;ZHANG Jing-shu;FAN Xiao-li;LI Xue-ping;ZHU Juan-xia(Department of Basic Medical,Xi′an Medical University,Xi′an 710021;Medical College,Hubei University of Arts and Science,Xiangyang 441053;Department of Medical,Xi′an Jiao Tong University,Xi′an 710016,China)

机构地区：[1]西安医学院基础医学部,西安710021 [2]湖北文理学院医学院机能学部,襄阳441053 [3]西安交通大学医学部,西安710016

出　　处：《生物学杂志》2018年第6期88-90,101,共4页Journal of Biology

基　　金：国家自然科学基金青年基金项目(31300981);陕西省自然科学基础研究计划资助项目(项目批准号2012JM4014);陕西省教育厅专项科研基金(2015JK1639)

摘　　要：Ca2+触发了肌肉的收缩,参与肌细胞活动的调节,钙稳态的维持对肌肉收缩功能具有重要作用。模拟失重条件下肌细胞钙稳态失衡与肌球蛋白表型的转换及骨骼肌收缩功能减弱关系密切。针对钙稳态的维持及模拟失重条件下的钙稳态失衡与肌萎缩的关系及其可能的机制进行了综述。Ca^2+triggers the contraction of muscle and participates in the regulation of muscle cells′activities.The maintenance of calcium homeostasis plays an important role in the muscle contractile function.The imbalance of calcium homeostasis,and the transition of myosin phenotype and the decrease of skeletal muscle contractile function are closely related to the simulated weightlessness.The relationship between calcium homeostasis and muscle atrophy under simulated weightlessness and the possible mechanism of calcium homeostasis are reviewed in this article.

关 键 词：模拟失重 CA^2+ 肌萎缩 

分 类 号：Q445[生物学—生理学]