SKA1及MMP-9在唾液腺腺样囊性癌组织中的表达及意义  

Expression and clinical significance of SKA1 and MMP-9 in primary salivary adenoid cystic carcinoma

作　　者：赵丽娟 张冬燕 高月华[3] 姜莉铖[2] 柳忠豪 张彬[2] ZHAO Lijuan;ZHANG Dongyan;GAO Yuehua;JIANG Licheng;LIU Zhonghao;ZHANG Bin(264000,Yantai Stomatological Hospital,China;Department of Oral and Maxillofacial Surgery,Liaocheng People’s Hospital;Dental College,Binzhou Medical College)

机构地区：[1]烟台市口腔医院,264000 [2]聊城市人民医院颌面外科 [3]滨州医学院口腔学院

出　　处：《实用口腔医学杂志》2018年第6期813-816,共4页Journal of Practical Stomatology

基　　金：山东省医药卫生科技发展计划项(编号:2017WS219)

摘　　要：目的:分析SKA1及MMP-9在唾液腺腺样囊性癌中的表达及临床意义。方法:采用免疫组织化学染色法检测42例腺样囊性癌组织及20例癌旁正常组织中SKA1及MMP-9的表达情况。结果:SKA1及MMP-9在唾液腺腺样囊性癌中的阳性表达率分别为78. 6%和66. 7%,明显高于其在癌旁正常组织中的表达(15%和25%)(P <0. 05)。SKA1及MMP-9的表达与临床分期及腺样囊性癌的组织病理类型关系密切(P <0. 05)。此外,MMP-9的表达尚与神经侵袭及生存时间关系密切(P <0. 05)。结论:SKA1及MMP-9在唾液腺腺样囊性癌组织中高表达可能成为SACC预后评估指标及潜在的治疗靶点。Objective:To investigate the expression and the clinical significance of spindle and kinetochore-associated complex subunit 1(SKA1)and matrix metalloproteinase-9(MMP-9)in salivary adenoid cystic carcinoma(SACC)tissues.Methods:SKA1 and MMP-9 expression in the samples from 42 cases of SACC and 20 of the normal tissue adjacent to carcinoma were detected by immunohistochemical test.Results:The positive rate of SKA1 and MMP-9 staining was 78.6%and 66.7%in SACC,respectively,significantly higher than those in normal salivary gland tissues(15%and 25%)(P<0.05).SKA1 and MMP-9 expression was positively associated with advanced stage and solid histological pattern of SACC(P<0.05).In addition,MMP-9 expression was positively associated with perineural invasion and survival time(P<0.05).Conclusion:SKA1 and MMP-9 may be promising prognostic factors and treatment target for salivary adenoid cystic carcinoma.

关 键 词：唾液腺腺样囊性癌(SACC) 纺锤体与动粒相关蛋白-1(SKA1) 基质金属蛋白酶-9(MMP-9) 

分 类 号：R739.8[医药卫生—肿瘤]