维生素K_4与甲硝唑联合牙周基础治疗术治疗慢性乙型肝炎肝硬化患者牙龈出血的疗效观察  

Short term efficacy of vitamin K_4 and metronidazole combined with periodontal initial therapy in treatment of gingival bleeding in patients with chronic hepatitis B cirrhosis

作　　者：陈云芳[1] 潘红英[2] 黄海军[2] CHEN Yunfang;PAN Hongying;HUANG Haijun(Department of Stomatology,Zhejiang Provincial People's Hospital/Affiliated Hospital of Hangzhou Medical College,Hangzhou 310014,China)

机构地区：[1]浙江省人民医院(杭州医学院附属医院)口腔科,杭州310014 [2]浙江省人民医院(杭州医学院附属医院)感染科,杭州310014

出　　处：《浙江医学》2018年第23期2549-2552,共4页Zhejiang Medical Journal

基　　金：浙江省医药卫生科技项目(2014KYB018)

摘　　要：目的观察维生素K_4与甲硝唑联合牙周基础治疗术治疗慢性乙型肝炎(CHB)肝硬化患者牙龈出血的短期疗效。方法纳入CHB肝硬化牙龈出血患者92例,按照随机数字表法分为3组,A组31例、B组31例、C组30例,A组单用维生素K_4,B组采用甲硝唑联合牙周基础治疗术,C组采用维生素K_4与甲硝唑联合牙周基础治疗术,3组均在治疗前及治疗完成后1个月进行牙周检查,观察指标包括探诊深度(PD)和龈沟出血指数(SBI)。结果 1个月后,C组的有效率高于B组,B组高于A组(P<0.05或0.01)。治疗前各组牙周指标比较差异均无统计学意义(均P>0.05);各组治疗后1个月较治疗前牙周指标均有明显改善(均P<0.01),且C组优于B组,B组优于A组,差异均有统计学意义(P<0.05或0.01)。结论维生素K_4能有效改善牙龈出血症状,维生素K_4与甲硝唑联合牙周基础治疗术治疗CHB肝硬化患者牙龈出血近期疗效好,值得临床推广。Objective To evaluate the effectiveness of vitamin K4 and metronidazole combined with periodontal initial therapy in the treatment of gingival bleeding in patients with chronic hepatitis B(CHB)cirrhosis. Methods Ninety-two CHB patients with gingival bleeding were randomly divided into three groups:patients in group A were treated with vitamin K4,patients in group B were treated with metronidazole combined with periodontal initial therapy,and patients in group C were treated with vitamin K4 and metronidazole combined with periodontal initial therapy.The probing depth(PD)and sulcus bleeding index(SBI)were observed at baseline and one month post-treatment by the same examiner. Results The short term efficacy of group C was higher than that of group B(P<0.05),and the efficacy of group B was much higher than group A(P<0.01).There were no significant differences in all periodontal indexes between the groups before treatment among 3 groups(P>0.05).While one month after treatment,the periodontal indexes of group C were better than those of group B(P<0.05),and the indexes of group B were better than those of group A(P<0.01). Conclusion Vitamin K4 and metronidazole combined with periodontal initial therapy is more effective in the treatment of gingival bleeding in chronic hepatitis B cirrhotic patients than single method.

关 键 词：肝硬化 牙龈出血 牙周基础治疗 维生素K4 甲硝唑 

分 类 号：R782.1[医药卫生—口腔医学] R512.62[医药卫生—临床医学]