辣木叶复方改善小鼠睡眠功能的实验研究  

Experimental Study of Horseradish Tree Leaves Improving Spleep in Mice

作　　者：张久旭 刘洋[1] 顾文宏 李梦薇 何军 赵保胜[1] ZHANG Jiuxu;LIU Yang;GU Wenhong;LI Mengwei;HE Jun;ZHAO Baosheng(Beijing University of Chinese Medicine, Beijing 102488, China;Yunnan Tianyou Technology Co. Ltd., Mangshi 678400, China)

机构地区：[1]北京中医药大学,北京102488 [2]云南天佑科技开发有限公司,云南芒市678400

出　　处：《中医药学报》2018年第6期39-43,共5页Acta Chinese Medicine and Pharmacology

基　　金：国家自然基金面上资助项目(81773960)

摘　　要：目的:观察辣木叶和辣木叶复方提取物对小鼠睡眠时间的影响。方法:ICR小鼠随机分为两个实验组,连续灌胃给药2周后,进行延长戊巴比妥钠睡眠时间实验和巴比妥钠睡眠潜伏期实验,观察受试药与戊巴比妥钠、巴比妥钠的协同催眠作用,比较各给药组对小鼠睡眠时间的影响。结果:与模型对照组比较,各给药组均能显著缩短巴比妥钠诱导的小鼠睡眠潜伏期(P <0. 01);辣木叶复方(1)和(2)可明显延长戊巴比妥钠诱导的小鼠睡眠时间(P <0. 05或P <0. 01),其他给药组未出现统计学差异,但是出现了延长睡眠时间的趋势。结论:辣木叶复方提取物具有改善小鼠睡眠功能的作用,其中,辣木叶复方(2)的作用最为明显。Objective:To observe the effect of the extracts from horseradish tree leaves and from compound Formula of horseradish tree leaves on sleeping time in mice.Methods:ICR mice were randomly divided into two experimental groups.Pentobarbital Sodiuma sleeping time test and Barbital Sodium sleep latency test were carried out after two weeks of medication.The synergistic hypnosis of the medication with Pentobarbital Sodiuma and with Barbital Sodium was observed to compare the effect on sleeping time by the medications.Results:Compared to the model group,the medication groups significantly shortened the sleep latency induced by Barbital Sodium(P<0.01).Compound Formula I and compound Formula II of horseradish tree leaves significantly prolonged the sleeping time induced by Pentobarbital Sodium(P<0.05,P<0.01);no significant difference was seen,but the trend of sleeping prolongation was shown in the other medication groups.Conclusion:Extracts of the compound formulas of horseradish tree leaves have the effect of improving sleep function in the mice,and the effect of Compound Formula II was the most obvious.

关 键 词：辣木叶 辣木叶复方 改善睡眠 

分 类 号：R285.5[医药卫生—中药学]