鞘氨醇-1-磷酸与卵巢癌的研究进展  

Research Progress in Sphingosine-1-phosphate and Ovarian Cancer

作　　者：宋柯琦[1] 戴岚[1] 狄文(审校)[1] SONG Ke-qi;DAI Lan;DI Wen(Department of Gynecology and Obstetrics,Shanghai Key Laboratory of Gynecologic Oncology,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院妇产科,上海市妇科肿瘤重点实验室,200127

出　　处：《国际妇产科学杂志》2018年第6期605-608,共4页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(81772770);上海市自然科学基金(18ZR1423100);上海市卫生和计划生育委员会“新优青计划”(2017YQ035)

摘　　要：鞘氨醇-1-磷酸(S1P)是鞘磷脂代谢产生的一种生物活性脂类,在多种癌症中对肿瘤具有促进作用。细胞内S1P生成由鞘氨醇激酶(SphKs)等调控,与相应受体(S1PR)结合发挥生物学效应。近年来涉及S1P与卵巢癌相关的研究提示卵巢癌患者中S1P呈高表达状态,其可以通过参与促进卵巢癌细胞的增殖和转移、抑制肿瘤细胞凋亡、诱导新生血管形成以及改变肿瘤免疫微环境状态等多种方式调节肿瘤细胞生物学行为,促进卵巢癌的发生和发展。阻断S1P信号传导途径中关键蛋白(包括S1P、SphK1、S1PR等)的相关药物能够抑制卵巢癌细胞生长及诱导细胞凋亡。因此,S1P相关途径可能成为卵巢癌治疗的潜在分子目标。本文简要综述了S1P信号通路在卵巢癌中的生理功能及相关药物研究进展。Sphingosine1-phosphate(S1P),a bioactive sphingolipid produced by the metabolism of sphingomyelin,is an important signaling regulator involved in tumor progression in multiple neoplasms.The formation of S1P is catalyzed by sphingosine kinases(SphKs),coupled with S1P receptors(S1PR)to exert effects.In recent years,studies involving S1P and ovarian cancer suggest that S1P is highly expressed in ovarian cancer patients.S1P,who can promote the proliferation and metastasis of ovarian cancer cells,inhibit apoptosis,change the tumor-associated microenvironment,is involved in the regulation of key cellular processes that contribute to ovarian cancer initiation and progression.Moreover,agents(S1P,SphK1,S1PR,etc.)who block the S1P signaling pathway inhibit ovarian cancer cell growth or induce apoptosis.Hence,current evidence suggests that S1P may become a potential molecular target for ovarian cancer therapy.This article briefly reviews the physiological functions of S1P signaling pathway in ovarian cancer and the research progress of related drugs.

关 键 词：鞘氨醇 磷酸类 卵巢肿瘤 细胞增殖 细胞凋亡 治疗 

分 类 号：R737.31[医药卫生—肿瘤]