肝门胆管癌合并阻塞性黄疸介入治疗的效果研究  

Evaluation of the Effect of Interventional Treatment for Hilar Cholangiocarcinoma With Obstructive Jaundice

作　　者：王刚[1] 桑海泉[2] 毕聪[3] WANG Gang;SANG Haiquan;BI Cong(Department of Intervention, The Fourth Affiliated Hospital of China Medical University, Shenyang Liaoning 110032, China;The Sixth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang Liaoning 110032, China;Radiology Department, The First Affiliated Hospital of China Medical University, Shenyang Liaoning 110001, China)

机构地区：[1]中国医科大学附属第四医院介入科,辽宁沈阳110032 [2]中国医科大学附属第四医院第六普通外科,辽宁沈阳110032 [3]中国医科大学附属第一医院放射科,辽宁沈阳110001

出　　处：《中国继续医学教育》2018年第35期86-89,共4页China Continuing Medical Education

基　　金：辽宁省科学技术计划项目(201501018)

摘　　要：目的探讨分析肝门胆管癌合并阻塞性黄疸介入治疗的效果。方法选取2015年7月—2016年6月于我院收治的肝门胆管癌合并阻塞性黄疸患者54例作为研究对象,所有患者均行介入治疗。收集患者术前肝功能、总胆红素水平、感染、阻塞类型、引流方式与并发症等可能影响治疗结果的因素,并对比术前与术后1周的肝功能指标与黄疸消除情况等。结果介入治疗成功53例,治愈率为98.1%,黄疸治愈48例,黄疸消除率为88.9%。与术前比较,术后患者血清中总胆红素(TBIL)、间接胆红素(IBIL)、谷丙转氨酶(ALT)与谷草转氨酶(GOT)水平均显著下降,差异均具有统计学意义(P <0.05)。结论对肝门胆管癌合并阻塞性黄疸患者采取介入治疗,可以明显改善肝功能、减轻黄疸,具有较好的治疗效果,对于改善疾病预后具有重要意义。Objective To investigate the efficacy of cholangiocarcinoma with obstructive jaundice in treatment of interventional drainage.Methods All54cases of patients which were selected from July2015to June2016in our hospital,and underwent in treatment of interventional drainage.The clinical data were retrospectively analyzed.The liver function,the levels of total bilirubin,directbilirubin and indirectbilirubin,obstructive type,infection,drainage methods were documented before operation.And the liver function and jaundice treatment efficiency were compared one week after the operation.Results Interventional therapy was successful in53cases,the cure rate was98.1%,jaundice was cured in48cases,and the elimination rate of jaundice was88.9%.The levels of total bilirubin(TBIL),indirect bilirubin(IBIL),alanine aminotransferase(ALT)and glutamic oxaloacetic aminotransferase(GOT)in serum of patients after operation were significantly lower than those before operation(P<0.05).Conclusion Interventional therapy for hilar cholangiocarcinoma with obstructive jaundice can significantly improve liver function and relieve jaundice.It has good therapeutic effect and is of great significance to improve the prognosis of the disease.

关 键 词：肝门胆管癌 黄疸 介入治疗 胆道内支架置入术 经皮肝穿刺胆管引流术 肝功能指标 

分 类 号：R735[医药卫生—肿瘤]