健脾益气方配合早期肠内营养对结直肠癌术后患者胃肠功能及血清miR-19a、TNF-α、IL-6水平的影响  

Effects of jianpi yiqi formula and early enteral nutrition on gastrointestinal function and the expressions of serum miR-19a,TNF-α and IL-6 in the patients after colorectal cancer surgery

作　　者：田军军[1,2] 陶然 曹才望[1,2] 夏绍友 李晨 TIAN Jun-jun;TA0 Ran;CA0 Cai-wang;XIA Shao-you;LI Chen(Department of General Surgery, Hubei Chinese Medicine Hospital, Wuhan Hubei 430061;Department of General Surgery,Hubei Academy of Chinese Medicine,Wuhan Hubei 430074;Department of General Surgery,General Hospital,PLA,Beijing 100853)

机构地区：[1]湖北省中医院普通外科,湖北武汉430061 [2]湖北省中医药研究院普通外科,湖北武汉430074 [3]中国人民解放军总医院普通外科,北京100853

出　　处：《世界中西医结合杂志》2018年第10期1414-1418,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：湖北省自然科学基金资助项目(2015CFB565)

摘　　要：目的观察健脾益气方配合早期肠内营养对结直肠癌术后患者胃肠功能及血清miR-19a、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平的影响。方法选取拟行结直肠癌手术患者102例作为研究对象,按照随机数字表法分为观察组和对照组各51例。两组均给予健康教育、饮食、运动等基础干预,在此基础上对照组给予早期肠内营养,观察组在对照组基础上配合健脾益气方治疗。观察两组中医证候积分、临床疗效、血清白蛋白(ALB)、前白蛋白(PA)、转铁蛋白(TF)、CD3+、CD4+、CD8+、CD4+/CD8+水平、胃肠功能以及血清miR-19a、TNF-α、IL-6水平。结果治疗后两组中医证候积分显著低于治疗前(P <0. 05),且观察组显著低于对照组(P <0. 05)。治疗后两组ALB、PA、TF显著高于治疗前(P <0. 05),且观察组显著高于对照组(P <0. 05)。观察组总有效率为88. 24%,显著高于对照组70. 59%(P <0. 05)。治疗后两组CD3+、CD4+、CD4+/CD8+显著高于治疗前(P<0. 05),且观察组显著高于对照组(P <0. 05),两组CD8+显著低于治疗前(P <0. 05),且观察组显著低于对照组(P<0. 05)。观察组首次肠鸣音时间、首次排便时间、首次排气时间、肠鸣音正常时间显著低于对照组(P <0. 05)。治疗后两组miR-19a、TNF-α、IL-6水平显著低于治疗前(P <0. 05),且观察组显著低于对照组(P <0. 05)。结论健脾益气方配合早期肠内营养能够有效改善结直肠癌术后患者胃肠功能,降低血清miR-19a、TNF-α、IL-6水平。Objective To observe the effects of jianpi yiqi formula and early enteral nutrition on gastrointestinal function and the expressions of serum miR-19a,TNF-αand IL-6in the patients after colorectal cancer surgery.Methods A total of102patients for the selective surgery of colorectal cancer were taken as the subjects.According to the random number table,they were divided into an observation group and a control group,51cases in each one.The basic intervention such as health education,dietary regulation and physical exercise was used in the two groups.Additionally,in the control group,the early enteral nutrition was applied.In the observation group,on the base of the treatment as the control group,jianpi yiqi formula was given.TCM symptom score,clinical efficacy,the levels of ALB,PA,TF,CD3^+,CD4^+,CD8^+and CD4^+/CD8^+,gastrointestinal function and the expressions of serum miR-19a,TNF-αand IL-6were observed in the two groups.Results After treatment,TCM symptom scores of the two groups were all lower than those before treatment(P<0.05).The score in the observation group was significantly lower than the control group(P<0.05).After treatment,the levels of ALB,PA and TF were significantly higher than those before treatment in the two groups(P<0.05)and the results in the observation group was significantly higher than the control group(P<0.05).The total effective rate was88.24%in the observation group,higher significantly than70.59%in the control group(P<0.05).After treatment,the levels of CD3^+,CD4^+and CD4^+/CD8^+were higher significantly as compared with those before treatment in the two groups.The results in the observation group were higher significantly than the control group(P<0.05).The level of CD8^+was lower significantly as compared with that before treatment in the two groups.The result in the observation group was lower signifi-cantly than the control group(P<0.05).In the observation group,the first bowel sound time,the first defecation time,the first flatus time and the recovery time of normal bowel sound were

关 键 词：健脾益气方 肠内营养 结直肠癌 胃肠功能 

分 类 号：R735.3[医药卫生—肿瘤]