葛根芩连汤加白及灌肠治疗慢性溃疡性结肠炎急性发作的效果  

Effects on the acute attack of chronic ulcerative colitis treated with gegen qinlian decoction plus rhizome bletillae and enema

作　　者：李淑红[1] 刘华一[2] 唐艳萍[1] LI Shu-hong;LIU Hua-yi;TANG Yan-ping(Tianjin Nankai Hospital,Tianjin 300100;Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine? Tianjin 300120)

机构地区：[1]天津市南开医院,天津300100 [2]天津市中医药研究院附属医院,天津300120

出　　处：《世界中西医结合杂志》2018年第10期1427-1430,共4页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的临床观察中药葛根芩连汤加白及保留灌肠对于慢性溃疡性结肠炎(CUC)急性发作的治疗效果及安全性。方法选取2016年2月至2016年6月期间收治的CUC急性发作期患者90例,中医辨证诊断均为湿热内蕴型,采用随机数表法分为A组30例(中药葛根芩连汤加白及联合保留灌肠内服外治),B组30例(服用中药葛根芩连汤),C组30例(服用西药整肠生胶囊),用药1个疗程后,对比三组患者的实验室检验学指标、中医症候积分改善水平、不良反应及总有效率。结果 (1)治疗后三组CUC患者血清中CRP、ESR水平及粪便中FCP、人S100钙结合蛋白A12(S100A12)含量指标降低水平与治疗前比较,差异有统计学意义(P <0. 05);且A组显著优于B组(P <0. 05),B组明显优于C组(P <0. 05);(2)治疗后三组CUC患者主症、次症积分和症候总积分与治疗前比较,差异有统计学意义(P <0. 05);且A组的主症、次症积分和症候总积分均显著优于B组和C组(P <0. 05),而B组明显低于C组(P <0. 05);(3) A、B、C三组CUC患者总有效率分别为96. 7%、80. 0%和53. 3%,三组比较A组显著优于B组(P <0. 05),B组明显优于C组(P <0. 05);(4)在不良反应率方面,A组和B组均显著低于C组(P <0. 05)。结论应用葛根芩连汤加白及保留灌肠法治疗CUC急性发作具有起效快速、不良反应少、疗效确切等优势,值得临床借鉴、推广。Objective To observe the clinical effects and safety on the acute attack of chronic ulcerative colitis(CUC)treated with gegen qinlian decoction plus rhizome bletillae and enema.Methods From February2016and June2016,90patients of CUC at the acute attack were collected.Based on TCM differentiation,all of the cases were diagnosed as the internal retention of damp heat.According to the random number table,they were divided into A group(30cases,treated with the combined therapy of oral administration and external application with gegen qinlian decoction plus rhizome bletillae and retention enema,B group(30cases,treated with oral administration of gegen qinlian decoction)and C group(30cases,treated with oral administration of bacillus licheniformis?capsules).After1session treatment,the laboratory indexes,TCM symptom scores,adverse reaction and the total effective rate were compared in the patients among the three groups.Results1.The levels of serum CRP and ESR and the levels of FCP and S100A12in the stool after treatment were different significantly as compared with those before treatment in the3groups.The results in the A group were better significantly than the B group(P<0.05)and those in the B group were obviously better than the C group(P<0.05).2.After treatment,the scores of the primary and secondary symptoms as well as the total score of the symptoms of CUC were different significantly as compared with those before treatment in the3groups(P<0.05).The results in the A group were better significantly than the B and C group(P<0.05)and those in the B group were lower obviously than the C group(P<0.05).3.The total effective rate was96.7%in the A group,80.0%in the B group and53.3%in the C group.The result in the A group was better significantly than the B group(P<0.05)and that in the B group was obviously better than the C group(P<0.05).4.Regarding the adverse reaction,the incidence in the A group and the B group was lower significantly than the C group(P<0.05).Conclusion The combined treatment with gegen qinlian decoc

关 键 词：中药葛根芩连汤加白及 灌肠 慢性溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]