UNC-51样激酶1在食管癌组织中的表达及其意义  

Expression and significance of UNC-51-like kinase 1 in esophageal carcinoma tissue

作　　者：刘欣韵 蒋小芹[1] 鲍晶晶[1] 窦蓉蓉 刘福兴[1] 戴桂红[1] 朱晓蔚[1] 陈民[2] 于鸿[1] LIU Xin-yun;JIANG Xiao-qin;BAO Jing-jing;DOU Rong-rong;LIU Fu-xing;DM Gui-hong;ZHUXiao-wei;CHEN Min;YU Hong(Department of Pathology,Taizhou Jiangsu 225300,China;Department of Dermatology,Taizhou People’s Hospital,Taizhou Jiangsu 225300,China)

机构地区：[1]泰州市人民医院病理科,江苏泰州225300 [2]泰州市人民医院皮肤科,江苏泰州225300

出　　处：《江苏大学学报（医学版）》2018年第6期521-524,共4页Journal of Jiangsu University：Medicine Edition

基　　金：泰州市社会发展项目(TS201625);泰州市人民医院院级课题(ZL201735)

摘　　要：目的:观察食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)组织中UNC-51样激酶1(UNC-51-like kinase 1,ULK1)的表达情况,并分析其与ESCC患者临床病理特征和生存期的关系。方法:利用组织芯片技术结合免疫组化法检测94例食管癌组织以及78例相应癌旁组织中ULK1蛋白的表达。结果:食管癌组织中ULK1细胞质表达水平显著高于癌旁组织(P <0. 01),且与淋巴结转移有明显相关性(P <0. 05)。生存分析显示,ULK1低表达的ESCC患者生存率明显低于高表达者(风险比为1. 754,95%CI:1. 022～3. 010,P=0. 041)。结论:ULK1在ESCC中异常表达,并且ULK1低表达ESCC患者的生存期较差,ULK1可能是ESCC潜在的分子标志物。Objective:To evaluate the association of UNC-51-like kinase 1(ULK1)expression with clinicopathological characteristics and survival time in patients with esophageal squamous cell carcinoma(ESCC).Methods:The expression levels of ULK1 in 94 ESCC and 78 paracancerous tissues were examined using immunohistochemical staining.Results:The levels of cytoplasmic ULK1 expression in ES CC tissues were higher than those in paracancerous tissues(P<0.01).ULK1 expression was significantly associated with lymphatic metastasis(_P<0.05)Survival analysis showed that patients with low ULK1 expression had shorter survival time than those with high ULK1 expression(hazard rate=1.754,95%CI 1.022-3.010,P=0.041).Conclusion:ULK1 was aberrantly expressed in ESCC.Patients with low ULK1 expression had shorter survival rate.ULK1 may be a potential prognostic biomarker for ESCC patients.

关 键 词：食管癌 UNC-51样激酶1 生物标志物 

分 类 号：R735.1[医药卫生—肿瘤]