生长抑素治疗恶性肠梗阻患者疗效的Meta分析  

Somatostatin for magligant bowel obstruction:A systematic review

作　　者：张翔 白鍊 简斌[1] 温泽霖 ZHANG Xiang;BAI Lian;JIAN Bing;WEN Zeling(Department of General Surgery,Yongchuan Hospital of Chongqing Medical University, Yongchnan 402160,Chongqing,China)

机构地区：[1]重庆医科大学附属永川医院普外科,重庆永川402160

出　　处：《西部医学》2018年第12期1810-1816,共7页Medical Journal of West China

基　　金：重庆市自然科学基金(2011BB5123)

摘　　要：目的系统评价生长抑素对恶性肠梗阻患者的治疗效果。方法计算机分别检索分别在PubMed、CNKI、万方、Cochrane Library 4个数据库,检索时间为2000年～2017年,以生长抑素、恶性肠梗阻、思他宁、益维宁为关键词,收集有关生长抑素治疗恶性肠梗阻相关的临床试验,对符合纳入标准的文献进行Jadad评分,分别提取各研究的基本情况以及实验组(生长抑素+常规治疗)与对照组(常规治疗)各项观测指标(腹痛腹胀缓解率、肛门排气排便缓解率、恶心呕吐缓解率、平均胃肠减压量、CRP、腹部平片、电解质紊乱改善率、平均住院日)的数据并使用Revman5.3进行统计学分析,根据各研究异质性结果分别采用固定或者随机效应模型合并效应值,最后对统计结果进行系统评价。结果共纳入研究10个,共计596名患者。Meta分析结果显示实验组在腹痛腹胀缓解率,肛门排气排便缓解率,腹部平片改善率,平均胃肠减压量等方面明显优于对照组,研究组平均住院日则低于对照组。结论生长抑素在恶性肠梗阻患者的临床症状缓解中生长抑素较常规治疗有着明显的优势,在恶性肠梗阻的治疗中具有确切效果。Objective To evaluate the effects of somatostatin for magligant bowel obstruction.Methods PubMed,CNKI,WANGFANG and Cochrane Library databases were searched to identify randomized controlled trials and quasi-randomized controlled trials of somatostatin which contained the conventional therapy with somatostatin versus conventional therapy for malignant bowel obstruction.We made a quality evaluation by Jadad scoring method,and used RevMan 5.3 statistic software to analyze the data in the articles,and then evaluated the results comprehensively.Results We found that 10 studies(596 patients)met the inclusion criteria.The results of meta-analyses is showed that there was a significant difference between the somatostatin with conventional and conventional in some Clinical symptoms.The abdominal pain relief rate,Anal exhaust defecation relief rate,Abdominal plain film improvement rate,mean gastrointestinal decompression of the study group were significantly higher than that of the control group.The average hospitalization day of study group was shorter than that of the control group.Somatostatin had obvious advantages over conventional treatment in the relief of clinical symptoms in patients with malignant intestinal obstruction.Conclusion Current evidence suggests that somatostatin combined with conventional therapy is superior to the conventional therapy for intestinal obstruction

关 键 词：生长抑素 恶性肠梗阻 思他宁 益维宁 

分 类 号：R574.2[医药卫生—消化系统] R975[医药卫生—内科学]