原发性肝癌并发2型糖尿病的相关因素分析  

Analysis on related factors of primary liver cancer complicated with type 2 diabetes mellitus

作　　者：宋浩成 莫宝庆[1] 薛学锋 严永锋[1,3] 黄新 SONG Haocheng;MO Baoqing;XUE Xuefeng;YAN Yongfeng;HUANG Xin(School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China;Physical Examination Center;Department of Etiology;Department of Clinical Laboratory, Qidong People’s Hospital, Qidong 226200,)

机构地区：[1]南京医科大学公共卫生学院,南京211166 [2]启东市人民医院体检中心,江苏启东2262000 [3]启东市人民医院病因室,江苏启东2262000 [4]启东市人民医院检验科,江苏启东2262000

出　　处：《癌症进展》2018年第14期1801-1803,共3页Oncology Progress

基　　金：南通市市级科技计划项目(GJZ17066)

摘　　要：目的探讨原发性肝癌并发2型糖尿病的影响因素。方法回顾性分析325例原发性肝癌患者的病历资料,根据是否患2型糖尿病将患者分为原发性肝癌糖尿病组(n=102)和原发性肝癌非糖尿病组(n=223)。比较两组患者的临床特征,并对原发性肝癌并发2型糖尿病的影响因素进行分析。结果原发性肝癌糖尿病组男性、年龄≥60岁、有饮酒史、乙型肝炎表面抗原(HbsAg)阳性及糖化血红蛋白(HbA1c)≥80%的比例均明显高于原发性肝癌非糖尿病组(P﹤0.01);多因素分析结果显示,男性、年龄≥60岁、有饮酒史、HbsAg阳性、HbA1c≥80%均为原发性肝癌并发2型糖尿病的独立危险因素(P﹤0.05)。结论原发性肝癌与2型糖尿病存在一定关系,男性、年龄≥60岁、有饮酒史、HbsAg阳性、HbA1c≥80%可作为原发性肝癌并发2型糖尿病的早期预警指标。Objective To investigate the factors related to type2diabetes mellitus in patients with primary liver cancer.Method A total of325patients with primary liver cancer were enrolled and were divided into primary liver cancer diabetic group(n=102)and primary liver cancer non-diabetic group(n=223)according to whether they had type2diabetes.The clinical characteristics of patients in the two groups were compared and the influencing factors of primary liver cancer complicated with type2diabetes mellitus were analyzed.Result In the primary liver cancer diabetic group,the proportions of patients with male gender,aged60years or older,history of drinking,positive hepatitis B surface antigen(HbsAg)and glycosylated hemoglobin(HbA1c)≥80%were significantly higher than those of patients in the primary liver cancer non-diabetic group(P<0.01).The results of multivariate analysis showed that the independent risk factors of primary liver cancer complicated with type2diabetes were the male gender,aged60years or older,drinking history,positive HbsAg and HbA1c≥80%(P<0.05).Conclusion Primary liver cancer is correlated with type2diabetes mellitus.Male gender,aged60years or older,alcohol consumption,positive HbsAg and HbA1c≥80%can be used as early warning indicators for primary liver cancer complicated with type2diabetes mellitus.

关 键 词：原发性肝癌 2型糖尿病 影响因素 

分 类 号：R735.7[医药卫生—肿瘤]