阿立哌唑与氟哌啶醇治疗儿童抽动障碍疗效的Meta分析  

Meta analysis of aripiprazole and haloperidol in the treatment of tic disorder in children

作　　者：王鑫[1] 徐冲锋 张敏[1] 吕攀攀[1] 刘芳[1] Wang Xin;Xu Chongfeng;Zhang Min;Lv Panpan;Liu Fang(Department of Child health Care,Affiliated Hospital of Binzhou Medical College,Shandong Binzhou 256603)

机构地区：[1]滨州医学院附属医院儿童保健科,256603

出　　处：《中国社区医师》2018年第34期72-73,75,共3页Chinese Community Doctors

摘　　要：目的:探讨阿立哌唑和氟哌啶醇治疗儿童抽动障碍的疗效。方法:检索2000年1月-2016年12月的国内外文献数据库,收集有关阿立哌唑与氟哌啶醇治疗儿童抽动障碍的对照研究,将符合纳入标准的文献进行Meta分析。结果:7个随机对照研究(共485个病例)纳入研究,显示在随访终点(8周)时阿立哌唑与氟哌啶醇的疗效差异无统计学意义,而不同治疗时间疗效的亚组分析显示,2周、4周和8周时与氟哌啶醇治疗抽动障碍比较,差异亦无统计学意义。结论:与氟哌啶醇相比,阿立哌唑在治疗儿童抽动障碍时疗效相当。Objective:To investigate the efficacy of aripiprazole and haloperidol in the treatment of tic disorder in children.Methods:We retrieved the main databases from January 2000 to December 2016,and collected the comparative studies of aripiprazole and haloperidol in the treatment of tic disorder in children,and analyzed the literature which met the inclusion criteria.Results:Seven randomized controlled trials(485 cases)were included.There was no significant difference in efficacy between aripiprazole and haloperidol at the end of the follow-up(8 weeks).Subgroup analysis of efficacy at different treatment times showed no significant difference between aripiprazole and haloperidol in treatment of tic disorder at 2,4,and 8 weeks.Conclusion:Aripiprazole is effective in the treatment of children with tic disorder compared with haloperidol.

关 键 词：阿立哌唑 氟哌啶醇 抽动障碍 META分析 儿童 

分 类 号：R749[医药卫生—神经病学与精神病学]