米氮平对抑郁症伴睡眠障碍患者抑郁症状、PSQI评分及睡眠结构的影响  

Effects of mirtazapine on depressive symptoms,PSQI score and sleep structure in patients with depression complicated with sleep disorders

作　　者：刘燕朋[1] 周进涛 连俊红[1] LIU Yan-peng;ZHOU Jin-tao;LIAN Jun-hong(Department of Second Psychiatry,Luoyang Mental Health Center,Luoyang 471000,China)

机构地区：[1]河南省洛阳市精神卫生中心精神二科,河南洛阳471000

出　　处：《实用药物与临床》2018年第12期1398-1401,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨米氮平对抑郁症伴睡眠障碍患者抑郁症状、匹兹堡睡眠质量指数量表(PSQI)评分及睡眠结构的影响。方法选取我院2016年1月至2017年2月收治的抑郁症伴睡眠障碍患者90例,采用随机数字法将其分为对照组和观察组,每组45例。对照组患者口服草酸艾司西酞普兰片治疗,在此基础上,观察组患者口服米氮平治疗。比较两组患者的治疗总有效率和不良反应发生率,以及治疗前后的蒙哥马利抑郁评定量表(MADRS)评分、PSQI评分和各睡眠结构因子。结果观察组的治疗总有效率明显高于对照组(91. 11%vs. 73. 33%,P=0. 02)。治疗后,观察组的MADRS评分和PSQI评分低于对照组(P <0. 01),睡眠效率高于对照组(P <0. 01),实际睡眠时间、NREM中S3+S4时间、REM时间均较对照组延长(P <0. 01),睡眠潜伏期、觉醒时间、NREM中S1+S2时间均较对照组缩短(P <0. 01)。两组患者的不良反应发生率比较差异无统计学意义(P>0. 05)。结论米氮平对抑郁症伴睡眠障碍患者的疗效显著,能够明显改善患者抑郁症状,改善睡眠质量,纠正睡眠结构,且治疗安全性较高。Objective To explore the effect of mirtazapine on depressive symptoms,Pittsburgh Sleep Quality Index(PSQI)score and sleep structure in patients with depression complicated with sleep disorders.Methods Totally90patients with depression complicated with sleep disorders in our hospital from January2016to February2017were randomly divided into control group and observation group according to random number method,45cases in each group.Patients in control group took estradiol oxalate tablets orally,while patients in observation group were treated with mirtazapine combined with estradiol oxalate tablets taken orally.The total effective rate and the incidence of adverse reactions,and the Montgomery Depression Rating Scale(MADRS)score,PSQI score and sleep structural factors were compared.Results The total effective rate in observation group was higher than that in control group(91.11%vs.73.33%=0.02).After treatment,the MADRS score and PSQI score in observation group were lower than those in control group(P<0.01),while the sleep efficiency in observation group was higher(P<0.01);the time of actual sleep,S3+S4in NREM and REM of observation group were longer than those in control group(P<0.01),while the latent period and the time of awakening and S1+S2in NREM in observation group were shorter(P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Mirtazapine is effective on depression complicated with sleep disorders,which can significantly improve the symptoms of depression and sleep quality and correct sleep structure,and the treatment is relatively safe.

关 键 词：米氮平 抑郁症 睡眠障碍 PSQI评分 睡眠结构 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R740[医药卫生—临床医学]