米氮平治疗围绝经期睡眠障碍患者的临床有效性及安全性分析  

Analysis on Clinical Efficacy and Safety of Mirtazapine in treatment of Patients with Perimenopausal Sleep Disorders

作　　者：孙瑞坦[1] 朴翔宇[1] 蔡鸣[1] 梁倩[1] SUN Ruitan;PIAO Xiangyu;CAI Ming(Zhongshan Hospital Affiliated to Dalian University,Liaoning Dalian 116001,China)

机构地区：[1]大连大学附属中山医院神经内科,辽宁大连116001

出　　处：《河北医学》2018年第12期2070-2073,共4页Hebei Medicine

基　　金：辽宁省科技攻关计划项目;(编号:20152650137)

摘　　要：目的:研究围绝经期睡眠障碍患者治疗中米氮平用药的临床疗效。方法:选取129例围绝经期综合征伴有睡眠障碍患者,按随机数字表法分为对照组(n=64例)和研究组(n=65例)。对照组患者给予谷维素片口服治疗,研究组患者给予米氮平片治疗。对比两组患者观察两组患者治疗前、治疗后4周、治疗后8周的PSQI评分、HAMD-17评分,睡眠临床疗效和抑郁临床疗效,对比治疗前、治疗4周后、治疗8周后脑电图结果及治疗过程中用药不良反应。结果:两组患者治疗前PSQI评分对比无显著性差异(P>0.05),治疗后两组患者4周、8周的PSQI评分均明显低于各自治疗前,且研究组患者评分均明显低于对照组(P<0.05)。对照组患者睡眠疗效总有效率显著低于研究组(χ~2=14.291,P <0.05)。治疗前两组患者HAMD-17评分对比无显著性差异(P>0.05),治疗后两组患者4周、8周的HAMD-17评分均明显低于各自治疗前,且研究组患者评分均明显低于对照组(P<0.05)。对照组患者抑郁疗效总有效率低于研究组(χ~2=12.621,P <0.05)。两组患者治疗前脑电图比较无显著性差异(P>0.05),治疗4周后两组亦无显著性差异(P>0.05),治疗8周后研究组显著好于对照组(P<0.05)。研究组患者不良反应发生率明显高于对照组(χ~2=4.737,P <0.05)。结论:在围绝经期综合征伴有睡眠障碍患者治疗中,米氮平起效快速,可改善睡眠,疗效显著,对脑电图影响较小,有一定不良反应,但需继续增加用药时间进一步观察。Objective:To study the clinical efficacy of mirtazapine in the treatment of patients with sleep disorders in perimenopausal period.Methods:129 cases of perimenopausal syndrome with sleep disorder were selected and divided into control group(n=64 cases)and research group(n=65 cases)according to random number table method.Patients in the control group were treated with oral oryzanol tablets.Patients in the study group were treated with mirtazapine tablets.The PSQI score,the HAMD-17 score,the clinical efficacy of sleep and the clinical effect of depression were compared between the two groups before treatment,4 weeks after treatment,and 8 weeks after treatment.The EEG results and adverse drug reactions before treatment,4 weeks after treatment and 8 weeks after treatment were compared.Results:There was no significant difference in PSQI scores between the two groups before treatment(P>0.05).After treatment,the PSQI scores at 4 weeks and 8 weeks were significantly lower in the two groups than before treatment.The scores of the study group were significantly lower than the control group.In the group(P<0.05).The total effective rate of sleep efficacy in the control group was lower than in the study group(χ2=14.291,P<0.05).There was no significant difference in HAMD-17 scores between the two groups before treatment(P>0.05).After treatment,HAMD-17 scores at 4 weeks and 8 weeks were significantly lower in the two groups than before treatment.The scores of the study group were Lower than the control group(P<0.05).The total effective rate of depression in the control group was lower than in the study group(χ2=12.621,P<0.05).There was no significant difference in EEG before treatment between the two groups(P>0.05).There was no significant difference between the two groups after 4 weeks of treatment(P>0.05).After 8 weeks of treatment,the study group was significantly better than the control group(P<0.05).The incidence of adverse reactions in the study group was higher than that in the control group(χ2=4.737,P<0.05).Conclusio

关 键 词：围绝经期综合征 睡眠障碍 米氮平 抑郁 脑电图 

分 类 号：R740[医药卫生—神经病学与精神病学]