宫颈高危型HPV检测联合阴道镜检查对宫颈癌前病变的预测价值的前瞻性队列研究  

Prospective Cohort Study on the Predictive Value of Cervical High-risk HPV Test Combined with Colposcopy in Cervical Precancerous Lesions

作　　者：屈海红[1] 赵帅华[1] 胡文娟 QU Haihong;ZHAO Shuaihua;HU Wenjuan(Anyang District Hospital of Puyang,Puyang,455000)

机构地区：[1]河南省濮阳市安阳地区医院,455000

出　　处：《实用癌症杂志》2018年第12期2073-2076,共4页The Practical Journal of Cancer

摘　　要：目的探究宫颈高危人乳头瘤病毒(hr HPV)联合阴道镜检查对宫颈癌前病变(CIN)预测的价值。方法选取进行CIN筛查的125例患者为研究对象,对所有患者行HPV-DNA检测及阴道镜检查,发现HPV-DNA阳性96例,阴性29例。同时行阴道镜检查,其中阳性患者86例,阴性39例。对所有患者随访1年,采用病理活检的方式记录是否出现CIN,记录HPV-DNA联合阴道镜检查阳性,分析其1年随访CIN发生率并分别与HPV-DNA、镜检进行对比。结果 HPV-DNA检测阳性患者1年CIN发生率为37. 5%(其RR值为0. 26),检测阴性患者其CIN发生率为3. 45%,差异具有统计学意义(P <0. 05);阴道镜检查阳性患者1年内CIN发生率为36. 05%(其RR值为0. 29),检测阴性患者其CIN发生率为5. 13%,差异具有统计学意义(P <0. 05)。单独HPV-DNA或单独阴道镜检查其RR值对比差异不具有统计学意义(P> 0. 05);而联合检测阳性患者其1年随访CIN发生率为57. 33%,其RR值为0. 06,对比HPV-DNA、镜检差异具有统计学意义(P <0. 05)。结论 hr HPV检测联合阴道镜检查对CIN发生具有较为准确的预测意义,能够作为CIN的初期检测依据。Objective To investigate the value of cervical intraepithelial neoplasia high risk human papillomavirus(hrHPV)combined with colposcopy in the prediction of cervical precancerous lesions(CIN).Methods 125 patients with CIN screening were selected for HPV-DNA test and colposcopy examination.The results showed that there were 96 cases of HPV-DNA positive and negative 29 cases were followed up for 1 year,the pathological biopsy of its presence or absence of CIN,all patients underwent colposcopy,of which 86 patients were positive,negative in 39 cases,the same were followed up for 1 year,using Histopathological examination of the presence or absence of CIN were recorded,and finally HPV-DNA combined with colposcopy positive patients were recorded and analyzed 1 year follow-up of CIN incidence and were compared with HPV-DNA and microscopic examination.Results The incidence of CIN at 1 year was 37.5%in patients with positive HPV-DNA test,and the RR was 0.26.The incidence of CIN was 3.45%in negative patients(P<0.05).The negative patients with positive colposcopy.The incidence of CIN in one year was 36.05%,and the RR was 0.29.The incidence of CIN in negative patients was 5.13%(P<0.05).The comparison of RR between HPV-DNA alone and colposcopy alone(P>0.05).However,the positive rate of CIN in one-year follow-up was 57.33%,and the RR was 0.06,which was significantly different from that of HPV-DNA and microscopic examination(P<0.05).Conclusion The combination of hrHPV test and colposcopy has a more accurate predictive value for CIN,which can be used as the initial detection basis of CIN.

关 键 词：hrHPV 阴道镜检查 CIN 前瞻性队列研究 

分 类 号：R737.33[医药卫生—肿瘤]